维持性血液透析患者动静脉内瘘血栓形成影响因素分析  

Influential factor analysis of thrombosis in internal arteriovenous fistula in maintenance hemodialysis patients

作　　者：马祖等 陈的铃 杨正林 张益民[2] 

机构地区：[1]深圳市横岗人民医院,深圳518115 [2]中山大学孙逸仙纪念医院肾内科,广州510120

出　　处：《中国血液净化》2009年第10期544-546,共3页Chinese Journal of Blood Purification

摘　　要：目的探讨维持性血液透析患者动静脉内瘘血栓形成的影响因素。方法观察首次动静脉造瘘的患者176例,每半年测定血清白蛋白(ALB)、C反应蛋白(CRP)、尿素氮(BUN)、β2-微球蛋白(β2-MG)、全段甲状旁腺激素(iPTH)以及血浆纤维蛋白质(Fib)和血红蛋白(Hb)等项目1次。对其中122例最终因血栓形成导致内瘘失功的患者进行相关因素与动静脉内瘘寿命之间COX回归分析。结果动静脉内瘘血栓形成与原发病为糖尿病、ALB、CRP、Fib存在回归关系。结论糖尿病、CRP、Fib是动静脉内瘘血栓形成的危险因素,ALB是动静脉内瘘的保护因素。Objective To investigate the influential factors relating to thrombosis in internal arteriovenous fistula in maintenance hemodialysis patients. Methods One hundred and seventy six cases with artificial arteriovenous fistulae for the first time were included in this study. Serum albumin, C-reactive protein, urea nitrogen, β- microglobulin and iPTH, plasma fibrinogen, and hemoglobin were assayed twice every year. In 122 cases with vascular access failure due to thrombosis in their internal arteriovenous fistulae, COX regression analysis were used to evaluate the correlation of these factors with the life span of arteriovenous fistulae. Result Diabetes, serum albumin, serum C-reactive protein and plasma fibrinogen correlated with the thrombosis in internal arteriovenous fistulae.Conclusion Diabetes, serum albumin, serum C-reactive protein, and plasma fibrinogen were the risk factors relating to thrombosis in internal arteriovenous fistula. Serum albumin was a protective factor.

关 键 词：维持性血液透析 动静脉内瘘 血栓形成 因素分析 

分 类 号：R318.16[医药卫生—生物医学工程]