肥胖儿童高尿酸血症的研究进展  

Advances in study on hyperuricemia of obese children

作　　者：方启宇[1] 万燕萍[1] 

机构地区：[1]上海交通大学医学院附属仁济医院临床营养科,上海200001

出　　处：《中国妇幼健康研究》2009年第5期588-591,共4页Chinese Journal of Woman and Child Health Research

摘　　要：儿童肥胖已成为突出的公共卫生问题。随着儿童肥胖症发生率的增加，高尿酸血症在儿童中发病率不断升高。儿童高尿酸血症可逐步发展为痛风、肾结石，且与心血管疾病、代谢综合征密切相关。虽然肥胖可通过游离脂肪酸、胰岛素抵抗、脂肪细胞因子、饮食、遗传等各种途径影响尿酸代谢，导致高尿酸血症，但是肥胖导致高尿酸血症的原因错综复杂，目前机制尚不明确。因此要加大对该病的研究力度，为预防和控制肥胖儿童高尿酸血症提供科学依据。The epidemic of obesity among children is a serious public health concern. The higher incidence of obesity in children causes increased incidence of hyperuricemia, which evolves gradually to gout, nephrolithiasis and is associated with development of cardiovascular diseases and metabolic syndrome. Although some related researches show that obesity impacts on uric acid metabolism and increases incidence of hyperuricemia via paths of free fatty acid, insulin resistance, adipocytokines, diet, heredity, the mechanisms how obesity cause hyperuricemia are quite complicated and unclear yet now. Therefore, the research on this condition should be strengthened,so as to provide scientific basis for preventing and controlling hyperuricemia of obese children.

关 键 词：肥胖症 高尿酸血症 儿童 胰岛素抵抗 脂肪细胞因子 

分 类 号：R725.8[医药卫生—儿科]