结核性胸膜炎患者胸水、血清铜蓝蛋白测定及临床意义  

The Ceruloplasmin Concentrations in Pleural Effusion and Serum in Tuberculous Pleurisy Patients and Their Clinical Value

作　　者：王梦义[1] 张宏[1] 李秋玲[1] 王玉宝[1] 于雅英 

机构地区：[1]天津医科大学第二医院内二科,300211

出　　处：《天津医药》1998年第12期730-732,共3页Tianjin Medical Journal

摘　　要：目的:探讨铜蓝蛋白(CP)与结核性胸膜炎患者的胸膜肥厚及粘连的关系。方法:用散射光比浊法对21例结核性胸膜炎患者的胸水和血清CP水平进行检测,并以15例癌性胸水患者及50例正常人作为对照。结果:结核性胸膜炎患者(Ⅰ组)血清CP水平明显高于对照组(Ⅲ组)(P<0.01),胸水消失后9例遗留胸膜肥厚、粘连患者(Ⅰ_1组)的胸水及血清CP水平明显高于12例无胸膜肥厚及粘连(Ⅰ_2组)患者(P<0.01),亦明显高于癌性胸水对照组(Ⅱ组),组间差异有显著性(P<0.01)。直线相关分析,Ⅰ_1组胸水与血清CP呈正相关(r=0.9943,P<0.001),Ⅰ_2组呈负相关(r=-0.7071,P<0.02)。结论:CP水平与结核性胸膜炎患者胸膜肥厚、粘连有一定关系,动态观察胸水及血清CP水平变化,有助于预测结核性胸膜炎患者是否将发生胸膜肥厚、粘连。To investigate the relationship between ceruloplasmin(CP) and pleral thickening and adhesion in patients with tuberculous(TB) pleurisy. Methods: CP concentrations in pleural effusion and serum were measured with scattered light turbidimetric method in 21 patients with TB pleurisy before administration of specific chemotherapy,and in 15 cacinomatous pleurisy patients and 50 normal controls. Results: Serum CP levels were significantly higher in patients with TB pleurisy than in normal controls( P < 0.01). Serum and pleural effusion CP levels in TB pleurisy patients with pleural thickening and adhesion were significantly higher than in those without pleural thickening and adhesion(P<0.01) ,and significantly higher than in cacinomatous pleurisy patients. Pleural CP levels were significantly positively correlated with serum CP levels in TB pleurisy patients with pleural thickening and adhesion( r = 0.9943, P < 0.001), while there was negative correlation between pleural CP levels and serum CP levels in those without pleural thickening and adhesion(r = -0.7071,F<0.02).Conclusion:CP levels were related to pleural thickening and adhesiion in patients with TB pleurisy. Dynamic observation of CP levels in pleural effusion and serum might be used in predicting the pleural thickening and adhesion in patients with TB pleurisy.

关 键 词：结核性胸膜炎 胸水 血浆 铜蓝蛋白 散射测浊法 

分 类 号：R521.704[医药卫生—内科学]