分阶段多准则立体定向放射治疗计划研究  

The Study of Multi-Phrase Multi-Criterion Steretactic Radiotherapy Treatment Planning

作　　者：吴新根[1] 吕维雪[2] 罗立民[1] 

机构地区：[1]东南大学,南京210096 [2]浙江大学,杭州310027

出　　处：《中国医疗器械杂志》1998年第6期319-323,共5页Chinese Journal of Medical Instrumentation

基　　金：中国博士后基金

摘　　要：立体定向放射治疗计划是X-刀放射治疗的重要组成部分。提出了一种分阶段多准则立体定向放射治疗计划理论，将优化过程分三个阶段。第一阶段利用线性规划法缩小解空间；第二阶段采用复形调优法以获得肿瘤区均匀且高的剂量分布；第三阶段采用有约束模拟退火法以获得符合临床实际的治疗效果。与三个优化阶段相对应的三个优化准则分别为：最大化肿瘤区与周围正常组织的积分剂量之差、肿瘤体积内均匀的剂量分布和基于放射生物学效应、符合临床实际的放射治疗统计模型、文中的实验结果也证实了上述理论的正确性。Steretactic radiotherapy treatment planning is an important part of X-knife radiosurgery. In this paper the theory of multi-phrase-multi-criterion steretactic radiothrapy treatment planning is proposed, which is composed of three phrases In the first stage, linear programming is used to reduce the resolution space. A kind of quadriatic programming is used in the second phrase in order to get high and well-distributed dose distribution. In the third phrase, an improved method of constrained simulated annealing is used to get the effect of comforming with the clinical practice. In correspondence with three-phrases optimization, three criterions are used respectively. The experiment results show that the theory proposed is correct.

关 键 词：肿瘤 立体定向术 放射疗法 放射治疗计划 

分 类 号：R815[医药卫生—放射医学] R730.55[医药卫生—临床医学]