矽肺患者血中一氧化氮和脂质过氧化水平的变化  

Changes in Blood Levels of Nitric Oxide, Oxidation and Lipoperoxidation in Patients with Silicosis

作　　者：周君富[1,2,3] 吴丹参 朱永平[1,2,3] 彭芬英 丁德云[1,2,3] 

机构地区：[1]浙江医科大学附属第二医院心脑血管病研究所 [2]杭州市职业病防治院 [3]浙江医科大学毒理研究室

出　　处：《中华预防医学杂志》1998年第6期333-335,共3页Chinese Journal of Preventive Medicine

摘　　要：目的探讨一氧化氮、氧化、脂质过氧化与矽肺的关系。方法检测７３例矽肺患者和６０例健康对照者血浆中一氧化氮（ＰＮＯ）、维生素Ｃ（ＰＶＣ）、维生素Ｅ（ＰＶＥ）、β－胡萝卜素（ＰβＣＡＲ）、过氧化脂质（ＰＬＰＯ）及红细胞中超氧化物歧化酶（ＥＳＯＤ）、过氧化氢酶（ＥＣＡＴ）、谷胱甘肽过氧化物酶（ＥＧＳＨＰｘ）、过氧化脂质（ＥＬＰＯ）值。结果与对照组比较，不同病情、不同肺功能状态患者组的ＰＶＣ、ＰＶＥ、ＰβＣＡＲ、ＥＳＯＤ、ＥＣＡＴ、ＥＧＳＨＰｘ平均值均显著降低，ＰＮＯ、ＰＬＰＯ、ＥＬＰＯ平均值均显著升高；各检测值与患病年限均有直线相关；逐步回归表明，病情、肺功能状态与ＰＮＯ、ＰＶＥ、ＥＳＯＤ、ＥＬＰＯ值相关最为密切。结论矽肺患者体内一氧化氮代谢异常，氧化、抗氧化平衡严重失调。Objective To explore the relationship between nitric oxide, oxidation, lipoperoxidation and silicosis. Methods Blood plasma levels of nitric oxide (P NO), vitamin C (P VC), vitamin E (P VE), β carotene (P β CAR), lipoperoxidase (P LPO), and erythrocyte activities of superoxide dismutase (E SOD), catalase (E CAT), glutathione peroxidase (E GSH Px) and lipoperoxidase (E LPO) were measured in 73 patients with silicosis and 60 healthy subjects. Results The average levels of P VC, P VE, P β CAR, E SOD, E CAT and E GSH Px were significantly lower and the average levels of P NO, P LPO and E LPO significantly increased in the silicosis with varied severity of the disease and lung function status more than in the controls. There was linear relationship between all the above indices and length of the disease. Stepwise regression analysis showed that the severity of the disease and lung function status correlated most closely with the levels of P NO, P VE, E SOD and E LPO. Conclusion Metabolism of nitric oxide was abnormal, balance between oxidation and antioxidation was disturbed seriously, and oxidation and lipoperoxidation reaction pathologically exacerbated in the bodies of the patient with silicosis.

关 键 词：矽肺 一氧化氮 脂质过氧化 

分 类 号：R135.2[医药卫生—劳动卫生]