瘢痕疙瘩不同部位P53的表达及其意义  

Expression and significance of P53 in different parts of keloid

作　　者：张刚[1] 汤少明[1] 梁杰[1] 赵明权[1] 余谦[1] 

机构地区：[1]广东医学院附属医院整形外科研究所,广东湛江524001

出　　处：《广东医学院学报》2009年第4期355-356,359,共3页Journal of Guangdong Medical College

基　　金：国家自然科学基金(No.30271344);广东省自然科学基金(No.020558);广东省社会发展领域科技计划项目(No.83034)

摘　　要：目的观察瘢痕疙瘩浸润部、增生部和老化部P53蛋白表达差异,以探讨瘢痕疙瘩呈浸润性生长的机理。方法取手术切除的瘢痕疙瘩组织及正常皮肤各16例为标本,对其行P53蛋白免疫组织化学染色,比较瘢痕疙瘩不同病理部位和正常皮肤P53表达差异。结果瘢痕疙瘩浸润部P53表达明显高于增生部、老化部和正常皮肤(P<0.01),瘢痕疙瘩增生部P53表达明显高于老化部和正常皮肤(P<0.01),而后两者间表达差异无统计学意义(P>0.05)。结论瘢痕疙瘩不同部位P53的表达差异可能是导致瘢痕疙瘩呈浸润性生长的机理之一。Objective To observe P53 expression from invasive,proliferative and aged parts of keloid to explore the aggres,sive growth characteristics of keloid. Methods surgical tissues of 16 keloids and 16 normal skins were investigated by immunohistochemistry with anti-P53 antibody. The P53 expression was observed and compared among different parts of keloid and normal skin. Results The P53 expression in the invasive part of keloid was stronger than those in the proliferative and aged parts of kdoid and normal skin （P〈0.01）. The P53 expression in the proliferative part in keloid was stronger than those in the aged part of keloid and normal skin （P 〈 0.01 ）. There was no significant difference of P53 expression between the aged part of keloid and the nomlal skin （ P 〈 0.05）. Conclusion High P53 expression may be one of possible reason accounting for the aggressive growth of keloid.

关 键 词：瘢痕疙瘩 P53蛋白 免疫组织化学 

分 类 号：R619.6[医药卫生—外科学]