缓激肽、离子通道与炎症性疼痛  

Bradykinin modulates ion channel in inflammatory pain

作　　者：刘伯一[1] 张海林[1] 

机构地区：[1]河北医科大学基础医学院药理学教研室,河北石家庄050017

出　　处：《药学学报》2009年第10期1066-1071,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金重点资助项目(30730031);国家高技术研究发展计划(863计划)资助项目(2006AA02Z183)

摘　　要：机体损伤或发生炎症时,受损或者发炎的组织释放诸多炎症介导因子。缓激肽是一种重要的炎症介导因子,在介导炎症性疼痛方面发挥重要作用。众所周知,痛觉的产生依赖于痛觉感受器表面分布的诸多离子通道的参与。近年来的研究显示,缓激肽在调控这些痛觉相关离子通道的功能与表达方面发挥重要作用,因此本文就缓激肽对痛觉相关离子通道调控作用的研究进展进行总结,并探讨治疗炎症性疼痛的未来方向。Injury or inflammation induces release of a range of inflammatory mediators. Bradykinin is one of the most important inflammatory mediators and plays a crucial role in mediating inflammatory pain. It is well known that multiple ion channels located in the nociceptors participate in pain sensation. Recent studies demonstrate an important role of bradykinin in regulating the function and expression of pain-related ion channels. This paper summarizes the recent advances in the understanding of the role of bradykinin in modulation of the channels and discusses future possibilities in the treatment of inflammatory pain.

关 键 词：缓激肽 离子通道 炎症性疼痛 

分 类 号：R963[医药卫生—微生物与生化药学]