Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords  

作　　者：Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen 

机构地区：[1]Institute of RF-& OE-ICs, Southeast University, Nanjing 210096, China [2]Key Laboratory of Neural Regeneration of Jiangsu Province, Nantong University, Nan tong 226001, China [3]State Key Laboratory of Bioelectronies, Southeast University, Nanjing 210096, China

出　　处：《Progress in Natural Science:Materials International》2009年第10期1261-1269,共9页自然科学进展·国际材料（英文版）

基　　金：supported by the National Natural Science Foundation of China (Grant Nos.69825101,30270391,30070255,and 90377013)

摘　　要：Due to the difficulty in spinal cord regeneration with biological methods, the microelectronic neural bridge, a new concept based on microelectronic technology, is presented. The microelectronic system has been realized in the forms of hybrid and integrated circuits. The integrated circuits for neural signal detection, stimulation, and regeneration are realized in a CMOS process. In animal experiments with 100 toads, 48 rats, and 3 rabbits, nerve signals have been successfully detected from spinal cords and sciatic nerves, and functional electrical stimulation has been carried out for spinal cords and sciatic nerves. When the microelectronic system is bridged between the controlling and stimulated nerve, the relevant motion of legs and nerve signal waveforms, which are stimulated by the evoked or spontaneous nerve signal through such a system, have been observed. Therefore, the feasibility of the presented method was demonstrated.Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated.

关 键 词：Nerve injury Microelectrode arrays Neural recordings NEUROSTIMULATION Functional recovery 

分 类 号：Q426[生物学—神经生物学]