Dynamic modeling of cellular response to DNA damage based on p53 stress response networks  

作　　者：Jinpeng Qi,Yongsheng Ding,Shihuang Shao College of Information Sciences and Technology,Donghua University,Shanghai 201620,China 

出　　处：《Progress in Natural Science:Materials International》2009年第10期1349-1356,共8页自然科学进展·国际材料（英文版）

基　　金：supported in part by the Specialized Research Fund for the Doctoral Program of Higher Education from the Ministry of Education of China (No20060255006);Project of the Shanghai Committee of Science and Technology (No 08JC1400100);and the Open Fund from the Key Laboratory of MICCAI of Shanghai(06dz22103)

摘　　要：Under acute perturbations from the outside,cells can trigger self-defensive mechanisms to fight against genome stress.To investigate the cellular response to continuous ion radiation(IR),a dynamic model for p53 stress response networks at the cellular level is proposed.The model can successfully be used to simulate the dynamic processes of double-strand breaks(DSBs) generation and their repair,switch-like ataxia telangiectasia mutated(ATM) activation,oscillations occurring in the p53-MDM2 feedback loop,as well as toxins elimination triggered by p53 stress response networks.Especially,the model can predict the plausible outcomes of cellular response under different IR dose regimes.Under acute perturbations from the outside, cells can trigger self-defensive mechanisms to fight against genome stress. To investigate the cellular response to continuous ion radiation （IR）, a dynamic model for p53 stress response networks at the cellular level is proposed. The model can successfully be used to simulate the dynamic processes of double-strand breaks （DSBs） generation and their repair, switch-like ataxia telangiectasia mutated （ATM） activation, oscillations occurring in the p53-MDM2 feedback loop, as well as toxins elimination triggered by p53 stress response networks. Especially, the model can predict the plausible outcomes of cellular response under different IR dose regimes.

关 键 词：P53 DNA damage IR Cellular networks Modelin 

分 类 号：Q78[生物学—分子生物学]