人早期胎盘SP受体的免疫组织化学研究  

Immunohistochemical study of substance P receptor in early human placenta

作　　者：姚兵[1] 黄威权[1] 孙岚[1] 

机构地区：[1]第四军医大学基础部组织胚胎学教研室,西安710033

出　　处：《第四军医大学学报》1998年第6期649-651,共3页Journal of the Fourth Military Medical University

摘　　要：目的：探讨人胎盘绒毛是否存在P物质（SP）受体及其细胞定位，为其对胎盘及胚胎发育的作用提供形态学依据．方法；采用免疫组织化学ABC法．结果：绒毛两层滋养层细胞，绒毛中轴的基质细胞，毛细血管的内皮细胞，毛细血管腔内的淋巴细胞以及血岛细胞均呈SP受体免疫反应阳性，阳性物质分布于胞质和胞膜上，胞核呈阴性反应．结论：胎盘产生的SP可能在其受体介导下参与胎盘激素合成和释放、胎盘毛细血管发生、微循环以及胚胎免疫功能的调节．Aim: To study whether substance P receptor(SPR) can exist in human placenta and their cellularlocalization in placental villi, and to supply morphologicalevidence for studying functional significance of the SP inplacenta and fetal development. Methods: Immunohistochemical ABC method was used to the experiment.Results: Both syncytiotrophoblast and cytotrophoblast,stromal cells, capillary endothelium, lymphocytes in capillarycavity,and all cells of blood islet in early human placentaswere all shown SPR immunoreactivity in cytoplasm withnegative nuclei. Conclusion: SP produced by placental villimay take part in regulation of synthesizing and releasing ofplacental hormone, and regulation of capillary developmentand microcirculation in placental villi, and regulation of fetalimmune fuction.

关 键 词：P物质 受体 胎盘 免疫组织化学 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学] R329.24[医药卫生—基础医学]