Evolutionary characteristics of exons expressed at different abundance levels in mammals  

作　　者：YU HaiJing FANG Lin LI Xin ZHANG XiaoYan YE Jia LI Jie HU WeiHong ZHENG BingRong XIAO ChunJie 

机构地区：[1]Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University, Kunming 650091, China [2]Beijing Genomics Institute at Shenzhen, Shenzhen 518083, China [3]CAS-Max Planck Junior Research Group and State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

出　　处：《Chinese Science Bulletin》2009年第19期3546-3554,共9页

基　　金：Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553);Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025);Undergraduate Science Novelty Training Project by Yunnan University Life Science Laboratory Center

摘　　要：With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and Ka/Ks analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms.With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and KalKs analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms.

关 键 词：哺乳动物 进化 特征 Ka/Ks 

分 类 号：Q95[生物学—动物学]