阿德福韦联合双环醇治疗慢性乙型肝炎疗效观察  

Therapeutic Effect of Combined Adefovir Dipivoxil and Bicyclol Treatment of Chronic Hepatitis B Infection

作　　者：孔霞[1] 张锐[1] 温瑾[1] 

机构地区：[1]河南省平顶山煤业集团总医院,平顶山467000

出　　处：《热带医学杂志》2009年第9期1028-1029,共2页Journal of Tropical Medicine

摘　　要：目的研究阿德福韦酯联合双环醇治疗慢性乙型肝炎的疗效。方法77例慢性乙型肝炎患者随机分为两组,试验组(39例)每日口服阿德福韦酯10mg、双环醇75mg;对照组(38例)每日仅口服阿德福韦酯10mg。两组均连续用药48周。观察治疗前后血清氨基转移酶、病毒学指标、肝脏影像学指标的改变。结果治疗48周后,试验组ALT复常率(87.18%)显著高于对照组(65.79%),HBV-DNA转阴率(64.10%)显著高于对照组(39.47%),影像学指标改善优于对照组,差异均有统计学意义(P<0.05)。结论阿德福韦酯与双环醇联合应用治疗慢性乙型肝炎能取得更好的生化学应答、病毒学应答和影像学改善。Objective To analyze the effectiveness of adefovir dipivoxil combined with bicyclol in the treatment of chronic viral hepatitis B （CHB）. Methods 77 patients with CHB were randomly divided into two groups, namely the experimental group and the control group. 39 patients in the experimental group orally received adefovir dipivoxil （10 mg/day） and bicyclol （75 mg/day） for 48 weeks. 38 control subjects received adefovir dipivoxil （10 mg/day） orally for 48 weeks. The level of serum aminotransferace （ALT）, HBV DNA, and imageological index were measured before and after treatment. Results The level of serum aminotransferace was obviously higher in the experimental group than the control group （87.18% vs 65.79%, P〈0.05）. HBV DNA negative conversion rate was significantly higher in the experimental group than the control group（64.10% vs 39.47%, P〈0.05）. The imageological index was also improved in the experimental group group （P〈0.05）. Conclusion Adefovir dipivoxil combined with bicyclol is effective in the treatment of chronic hepatitis B infection.

关 键 词：慢性乙型肝炎 阿德福韦酯 双环醇 

分 类 号：R512.62[医药卫生—内科学]