顶空气相色谱法测定糖脂清片中大孔吸附树脂有机残留物  

Determination of organic residues in macroporous adsorption resins of Tangzhiqing Tablet by headspace gas chromatography

作　　者：郝彧[1] 刘虹[1] 吴帅[1] 张德芹[1] 潘桂湘[1] 

机构地区：[1]天津中医药大学中医药研究中心,省部共建教育部方剂学重点实验室,天津300193

出　　处：《中成药》2009年第9期1405-1408,共4页Chinese Traditional Patent Medicine

基　　金：教育部高等学校科技创新工程重大项目培育资金项目(706013)

摘　　要：目的:建立糖脂清片中大孔吸附树脂有机溶剂正己烷、苯、甲苯、对二甲苯、间二甲苯、邻二甲苯、苯乙烯和二乙烯苯的残留量检测法。方法:采用顶空气相色谱法检测,色谱柱为HP-INNOWAX毛细管柱;检测器为氢火焰离子化检测器,载气为高纯氮。结果:该法线性良好,r值均在0.992 6～0.999 9之间;方法精密度、重现性相对标准偏差(RSD)均小于5.0%,样品加样回收率(n=9)为99.7%～117.0%。结论:该法操作简便快速,准确度好,灵敏度高,可用于糖脂清片中8种有机溶剂残留量的测定。AIM： To establish a method for simultaneously determining hexane, benzene, toluere, p-xylene, m-xylene, o-xylene, styrene, divinyl-benzene in macroporous resin in processing Tangzhiqing Tablet. METHODS： The contents of organic residues were determined by headspace gas chromatography on HP-INNOWAX column, with FID detector, high purity nitrogen as the carrier gas. RESULTS： It appeared a good linearity in the experimental concentration （ r = 0.992 6 - 0.999 9）. The RSDs of precision and accuracy were less than 5.0%, and the recoveries for spiked Sample （ n = 3 ） were in the range of 99.7% - 117.0%. CONCLUSION ： The method is proved to be sensitive, simple, accurate and suitable for the determination of eight residual organic solvents of macro-porous resin in Tangzhiqing Tablet.

关 键 词：糖脂清片 大孔吸附树脂 顶空气相色谱法 有机残留物 

分 类 号：R284.1[医药卫生—中药学]