2型糖尿病血小板活化与血糖变化的相关分析  

Significance of Detection of Platelet Activation Function and the Change of Blood Sugar in Patients with Type 2 Diabetes Mellitus

作　　者：葛繁梅[1] 高延慧[1] 高雪梅[1] 李风鸣[1] 贺春英[1] 刘宇宏[1] 苏保雄[1] 任羽[1] 曹慧琴[1] 刘延香[1] 

机构地区：[1]延安大学附属医院血液免疫科,延安716000

出　　处：《血栓与止血学》2009年第5期213-215,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨糖尿病患者糖化血红蛋白水平与血小板膜GPⅡb/Ⅲa复合物纤维蛋白原受体(PAC-1)和P选择素(CD 62P)的关系及其临床意义。方法采用流式细胞仪三色荧光标记技术来测定45例40岁以下初发的2型糖尿病患者及20名健康对照组的PAC-1、CD 62P的表达率和糖化血红蛋白A1(GHbA1)比率,同时进行治疗前后及与对照组比较。结果初发的2型糖尿病组PAC-1(12.38±3.15%)、CD 62P(8.74±2.01%)、GHbA1(9.53±2.73%),其表达分别显著高于健康对照组的2.67±1.52%(P<0.001)、1.07±1.41%(P<0.001)、6.21±1.05%(P<0.001)。降糖治疗6月后糖尿病组血糖达标,PAC-1(7.38±3.25%)、CD 62P(6.26±3.01%)、GHbA1(6.33±1.46%),与治疗前比较有显著差异(P<0.001)。结论2型糖尿病血小板活化与糖化血红蛋白水平密切相关。严格控制血糖可以抑制血小板活化,预防血栓性疾病的发生。Objective To investigate the relation and clinical significance of platelet membrane glucoprotein Ⅱ b/Ⅲa complex fibrinogen receptor （PAC-1 ）, CD 62P expression and glucosylated haemoglobin on platelet activation function in patients with type 2 diabetes mellitus. Methods Platelet PAC- 1, CD 62P expression were analyzed by flow cytometry （FCM） and their glucosylated haemoglobin （ GHbA1 ） was determinedin in 45 diabetes mellitus patients ,and compared with patients group,itself group of the after trentment and normal controls. Results The positive rates of PAC- 1 （ 12.38 ± 3.15% ）, CD 62P（8.74 ± 2.01% ） and the rate of GHbA1 （9.53 ± 2.73 % ） in 35diabetes mellitus patients were significantly higher than itself group of the after trentment （ 7.38 ± 3.25 % ） （ P 〈 0. 001 ）, （ 6.26± 3.01% ） （ P 〈 0.001 ）, （ 6.33 ± 1.46 % ） （ P 〈0.010） ;and the normal controls （2.67± 1.52% ）（P〈0.001） ,（1.07±1.41% ）（P〈0.001） ,（ 6.21 ±1.05 % ） （ P 〈 0. 001 ）. Conclusion Platelet activation function in type2 diabetes mellitus is related with glucosylated haemoglobin ,strict controlled glueosylated haemoglobin can restain platelet activation, and can prevent thrombosis disease.

关 键 词：2型糖尿病 糖化血红蛋白 血小板膜GPⅡ b/Ⅲa复合物纤维蛋白原受体 P选择素 

分 类 号：R587.1[医药卫生—内分泌]