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机构地区:[1]江西省食品药品检验所,南昌330029 [2]总后勤部卫生部药品仪器检验所,北京100071
出 处:《药物分析杂志》2009年第10期1621-1623,共3页Chinese Journal of Pharmaceutical Analysis
摘 要:目的:建立用高效液相色谱方法测定注射用拉氧头孢钠的有关物质。方法:采用Diomonsil C18柱(150mm×4.6mm,5μm),以0.01mol·L-1醋酸铵溶液-甲醇(19∶1)为流动相,流速为0.5mL·min-1,以自身对照法测定,检测波长为254nm。结果:线性范围为26.52~1065.8ng,r=0.9999,最低检测限为0.02ng。结论:该方法准确、简便,可以用于注射用拉氧头孢钠的有关物质测定。Objective:To determine the related substances in latamoxef sodium for injection by HPLC. Method: Column was Diomonsil C18 ( 150 mm×4.6mm,5μm), the mobile phase was 0. 01 mol· L-1 ammonium acetate and methanol in the ratio of 19: 1. The detection wavelength was 254 nm and the flow rate was 0. 5 mL · min^-1. Resuits :Excellent linear relation in the range of 26.52 - 1065.8 ng( r = 0. 9999)was observed in latamoxef. The limit of detection was 0.02 ng. Conclusion:The method is accurate and simple and it can be used for determination of the related substances in latamoxef sodium for injection.
分 类 号:R917[医药卫生—药物分析学]
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