2562例他达拉非不良反应报告分析  

Adverse Drug Reactions Induced by Tadalafil:Analysis of 2 562 Cases

作　　者：陈亮[1,2] 贾金铭[2] 钟伟[1] 王明晓[1] 

机构地区：[1]国家安全生产监督管理总局煤炭总医院泌尿外科,北京市100028 [2]中国中医科学院广安门医院,北京市100053

出　　处：《中国医院用药评价与分析》2009年第10期786-788,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金资助项目(项目批准号30901492)

摘　　要：目的:比较和探讨他达拉非(希爱力)可疑不良反应发生的特点,旨在对临床规范用药提供有益借鉴。方法:查阅世界卫生组织药品不良反应数据库,检索并分析药品的不良反应报告。结果:药品不良反应报告主要集中在心血管、神经、消化等系统。严重不良反应如异常勃起的报告率逐年下降。结论:应该继续规范药物的临床应用,以尽量减少心肌梗死、异常勃起等严重不良反应的发生,对肺动脉高压、神经再生等病症的应用研究更应该谨慎进行。OBJECTIVE： To compare and evaluate the characteristics of the suspected ADRs induced by Tadalafil in order to offer beneficial reference for clinical standard medication. METHODS： The ADR cases induced by Tadalafil collected from WHO ADR database were analyzed. RESULTS： The ADRs of Tadalafil mainly appeared in cardiovascular system, nervous system and digestive system. The reporting ratio of the serious ADR such as priapism decreased year by year. CONCLUSION ： Continuing efforts should be paid to the standard use of Tadalafil in order to reduce the incidence of its serious ADRs such as myocardial infarction and priapism etc. The clinical trial on Tadalafil in the treatment of pulmonary hypertension and neurogenesis et al should be conducted with more caution.

关 键 词：他达拉非 不良反应 分析 

分 类 号：R969.3[医药卫生—药理学]