消郁安神胶囊对慢性应激抑郁模型大鼠空间学习记忆能力的影响  

Effect of Xiaoyu Anshen Capsule on Space Learning-memory Ability of Chronic Stress-induced Depressed Model Rats

作　　者：王天文[1,2] 周远大[1] 张莉[2] 蒋渝[2] 秦剑[2] 黄思行[2] 何沛霖[2] 李卿[2] 

机构地区：[1]重庆医科大学,重庆市400016 [2]重庆市中药研究院,重庆市400065

出　　处：《中国药房》2009年第30期2329-2331,共3页China Pharmacy

基　　金：重庆市自然科学基金计划项目(CSCT,2007BB5257)

摘　　要：目的:研究消郁安神胶囊对慢性应激抑郁模型大鼠空间学习记忆能力的影响。方法:实验分为6组,即空白对照、模型对照、百忧解及消郁安神胶囊高、中、低剂量组。采用慢性应激和孤养的方法复制慢性应激抑郁大鼠模型。通过水迷宫视频跟踪分析系统检测大鼠空间学习记忆能力,测定大鼠复制模型前、后的体质量增长数、蔗糖溶液消耗量等指标。结果:与空白对照组比较,模型对照组大鼠空间学习记忆能力显著下降,体质量增长数、蔗糖溶液消耗量显著减少;与模型对照组比较,消郁安神胶囊高、中、低剂量组大鼠逃避潜伏期显著缩短,消郁安神胶囊高、中剂量组大鼠穿越隐匿平台次数及体质量增长数增加,消郁安神胶囊高剂量组大鼠蔗糖溶液消耗量增加。结论:消郁安神胶囊对慢性应激抑郁模型大鼠体质量、蔗糖溶液消耗量的异常有抑制作用,并能提高其空间学习记忆能力,是具有益智作用的抗抑郁中药。OBJECTIVE： To explore the effect of Xiaoyu anshen capsule on the space learning - memory ability of chronic stress-induced depressed model rats.METHODS： The enrolled rats were divided into 6 groups： blank control group, model group, Fluoxetine group, Xiaoyu anshen capsule groups（high,medium and low dose）. Chronic depression rat model was induced by chronic stress and isolated breeding. Water- maze video tracking analysis system was used to detect the capacity of rats＇ space learning - memory, and the indexes such as the body weight of rats before and after modeling and the consumption of sucrose,etc.were measured. RESUTLS： Compared with the blank control group, the model control group showed significantly decreased space learning-memory capacity, significantly lower in body weight increase and significantly less sucrose solution consumption. Compared with the model control group, the high, medium and low dose Xiaoyu anshen capsule-treated group showed significantly shortened escape latency, the high and medium dose groups showed increased number of times of crossing the hidden platform and body weight increase, and in high dose Xiaoyu anshen capsale group sucrose consumption increased.CONCLUSION： Xiaoyu anshen capsule is a nootropic Chinese herbal medicine for its inhibitory effect on the abnormality in body weight and sucrose solution consumption of chronic stress induced depressed model rats and their action in enhancing the space learning-memory ability.

关 键 词：消郁安神胶囊 慢性应激 抑郁模型 空间学习记忆能力 大鼠 

分 类 号：R285[医药卫生—中药学] R97[医药卫生—中医学]