七叶皂苷钠对大鼠弥散性脑损伤合并二次脑损伤的保护作用研究  

Protective Effect of β-sodium Aescinate against Secondary Brain Injury in Rats with Diffuse Brain Injury

作　　者：罗宁[1] 蔡威黔[1] 林锦波[1] 颜晗[2] 张华翔 

机构地区：[1]深圳市龙岗区人民医院,深圳市518172 [2]深圳市药品检验所,深圳市518019 [3]深圳市人民医院,深圳市518019

出　　处：《中国药房》2009年第30期2331-2333,共3页China Pharmacy

基　　金：深圳市龙岗区科技计划项目(深龙科[2008]24-75)

摘　　要：目的:研究七叶皂苷钠对大鼠弥散性脑损伤合并二次脑损伤的保护作用。方法:实验分为4组,即对照、模型及七叶皂苷钠高、低剂量组,分别测定大鼠脑组织白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、内皮素(ET)和一氧化氮(NO)水平。结果:与对照组比较,模型组大鼠脑组织IL-1β、TNF-α、ET和NO水平显著升高(P<0.05);与模型组比较,七叶皂苷钠高剂量组大鼠脑组织IL-1β、TNF-α、ET和NO水平显著下降(P<0.05)。结论:七叶皂苷钠可通过抑制炎性因子、清除氧自由基和稳定血管内皮细胞等机制发挥保护神经组织的作用。OBJECTIVE： To investigate the protective effect of β- sodium aescinate against secondary brain injury in rats with diffuse brain injury. METHODS： The experimental rats were randomized to 4 groups： control group, model group, high dose aescinate group and low dose aescinate group. IL- 1β, TNF- α, ET （endothelin） and NO levels in brain tissues of the 4 groups were measured. RESULTS： As compared with the control group, levels of IL - 1β, TNF - α, ET and NO in rat brain tissues in model group significantly increased（P 〈 0.05） . In high dose aescinate group compared with the model group, levels of IL- 1β, TNF-α, ET and NO in rat brain tissues significantly decreased（P 〈 0.05）. CONCLUSION： The neuroprotective effect of β- sodium aescinate might be achieved by inhibiting inflammatory factor, scavenging oxygen free radicals and stabilizing vascular endothelial cells,etc.

关 键 词：七叶皂苷钠 弥散性脑损伤 二次脑损伤 白细胞介素-1Β 肿瘤坏死因子-Α 内皮素 一氧化氮 大鼠 

分 类 号：R285[医药卫生—中药学] R97[医药卫生—中医学]