星点设计法优化黄芩素缓释微球制备工艺  

Optimization of the Preparation Technology of Baicalein Sustained Release Microspheres by Central Composite Design

作　　者：于立军[1] 方银杏 邹爱峰[3] 胡容峰[4] 

机构地区：[1]南京军区南京总医院疗养区药械科,南京市211131 [2]南京康能生物工程有限公司,南京市210005 [3]中国药科大学药剂教研室,南京市210009 [4]安徽中医学院药剂教研室,合肥市230038

出　　处：《中国药房》2009年第30期2349-2352,共4页China Pharmacy

摘　　要：目的:优化黄芩素缓释微球的制备工艺。方法:采用溶剂挥发法制备黄芩素缓释微球。以骨架材料质量比、水相中十二烷基硫酸钠(SDS)浓度、投药量为自变量,2h药物累积释放度(Y1)、12h药物累积释放度(Y2)、24h药物累积释放度(Y3)为因变量,分别进行多元线性回归和二次多项式拟合。结果:按处方工艺制备的微球形态圆整;优化的工艺为投药量25%,骨架材料质量比3.5,SDS浓度0.08%;Y1、Y2、Y3分别为21.05%、55.70%、87.75%;3个方程均为二次多项式拟合的效果较好。结论:星点设计法使用方便、预测性良好,值得推广应用。OBJECTIVE： To optimize the preparation technology of Baicalein sustained release microspheres. METHODS： The microspheres containing baicalein were prepared using solvent evaporation technique. Multiple linear regression equation and quadratic polynomial equation were fitted respectively with the mass ratio of the matrix materials, sodium dodecyl sulfate （SDS） concentration in water phase and drug content as independent variables, and with the accumulative drug release percentage at 2, 12 and 24 h（ Y1, Y2, Y3） as dependent variables. RESULTS： The baicalein sustained release microspberes prepared in accordance with the above technology were spherical and even. The optimized technical conditions were as follows： the drug content was 25% ; the ratio of the matrix materials was 3.5; SDS concentration was 0.08% ; Y1, Y2 and Y3 were 21.05%, 55.70% and 87.75%, respectively. All the three equations fitted using quadratic polynomial equations achieved good fitting results. CONCLUSION： Central composite design is convenient to use and it has satisfactory predictability thus deserving popularization.

关 键 词：黄芩素 缓释微球 星点设计法 制备工艺 

分 类 号：R283[医药卫生—中药学] R283.69[医药卫生—中医学]