生姜抗晕动病有效部位化学成分分析  

Analysis of Chemical Compositions of the Effective Anti-kinesia Fraction from Zingiber officinale

作　　者：宣伟东[1] 卞俊[1] 刘娟[1] 王朝武[1] 袁兵[1] 

机构地区：[1]解放军第411医院南京军区药学专科中心,上海市200434

出　　处：《中国药房》2009年第30期2362-2364,共3页China Pharmacy

摘　　要：目的:分析生姜抗晕动病有效部位的化学成分。方法:用正己烷提取有效部位,采用气相色谱-质谱联用(GC-MS)法分析提取物中化学成分;采用高效液相色谱(HPLC)法测定提取物中抗晕活性成分6-姜酚的含量。结果:GC-MS法测定提取物中烯类占61.41%,姜酚类占21.60%,姜酮类占4.90%,醇类占2.74%,含量较高的为姜烯(23.596%)和6-姜酚(15.004%);HPLC法测定提取物中6-姜酚的含量为15.97%。结论:生姜抗晕动病有效部位中烯类和姜酚类成分含量较高。HPLC法可作为生姜抗晕动病有效部位6-姜酚的质控方法。OBJECTIVE ： To analyze the chemical compositions of the effective anti - kinesia fraction of Zingiber officinale .METHODS： The effective fraction was extracted by using n-hexane, and the chemical compositions of the extract were analyzed by GC-MS. The content of 6- gingerol in n-hexane extract was determined by HPLC. RESULTS： The constituents of effective fraction were composed of alkenes（61.41% ）, gingerols（21.60% ）, gingerones（4.90 % ） and alcohols （2.74%）, with Zingiberene（23. 596% ） and 6-gingerol（ 15.004% ） taking the lead in terms of content. The content of 6-gingerol which determined by HPLC was 15.97%. CONCLUSION： The contents of alkenes and gingerols are high in the effective anti- kinesia fraction of Z.officinale .HPLC can be used as a quality control method for the 6-gingerol in the effective anti- kinesia fraction of Z.officinale.

关 键 词：生姜 6-姜酚 晕动病 气相色谱-质谱联用法 高效液相色谱法 

分 类 号：R284.1[医药卫生—中药学] R914[医药卫生—中医学]