杨梅素对小鼠被动皮肤过敏反应的影响  

Effect of myricetin on passive cutaneous anaphylaxis in mice

作　　者：佟岩[1] 王淑君[2] 周晓棉[1] 曹颖林[1] 

机构地区：[1]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2009年第10期822-825,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的研究杨梅素的抗过敏作用。方法采用小鼠同种、异种被动皮肤过敏反应(PCA)、右旋糖酐致小鼠全身瘙痒反应和2,4-二硝基氯苯(DNCB)所致小鼠耳廓皮肤迟发型超敏反应(DTH)实验,探讨杨梅素的抗过敏作用。结果杨梅素显著抑制小鼠同种、异种被动皮肤过敏反应和右旋糖酐引起的小鼠瘙痒反应,并能抑制DNCB诱导的DTH。结论杨梅素具有抗过敏作用,机制可能与抑制Ⅰ、Ⅳ型变态反应有关。Objective To study antianaphylaxis activities of myricetin. Methods The antianaphylaxis activities of myricetin was measured by passive cutaneous anaphylaxis （PCA）, dextran-induced itch and DNCB-induced delayed type hypersensitivity （DTH）in mice, respectively. Results Myricetin showed a significant inhibition on PCA and dextran-induced itch, it also inhibited DNCB-induced DTH in mice. Conclusions These results indicate that the potent antianaphylaxis effect of myricetin may be associated with the inhibition of type Ⅰ and type Ⅳ allergic reaction.

关 键 词：杨梅素 抗过敏 被动皮肤过敏反应 瘙痒反应 迟发型超敏反应 

分 类 号：R96[医药卫生—药理学]