二黄散清除hrHPV的机制  

Mechanism of Huang San Ⅱ on hrHPV

作　　者：程艳香[1] 江敬红[1] 洛若愚[1] 刘嵘[2] 尹伶[3] 张蔚[1] 

机构地区：[1]武汉大学人民医院妇产科,湖北武汉430062 [2]中国人民解放军161空军医院妇产科,湖北武汉430010 [3]武汉科技大学附属医院妇产科,湖北武汉430062

出　　处：《中国医院药学杂志》2009年第20期1773-1775,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨含砷复方中药"二黄散"对人乳头状瘤病毒(hrHPV)的作用机制及其治疗宫颈hrHPV阳性者的效果。方法:将二黄散作用于宫颈hrHPV阳性者的宫颈表面。治疗前和治疗后6月分别采用杂交捕获二代法(HC-Ⅱ)检测宫颈局部HPV转阴率,酶联免疫吸附试验ELISA检测血清干扰素γ(IFN-γ)、肿瘤坏死因子α(TNF-α)、白介素4(IL-4)、IL-10水平。结果:治疗后HPV转阴率明显上升、IL-4及IL-10水平均下降,IFN-γ和TNF-α水平上升,治疗前后结果比较均具有显著性差异,且HPV的变化与上述因子水平改变相关。结论:二黄散可能通过调节Th1/Th2的免疫平衡清除hrHPV病毒,可以作为临床治疗hrHPV阳性患者的有效手段。OBJECTIVE To evaluate the mechanism of the compound Chinese medicine including arsenic ＂Huang San Ⅱ ＂ on hrHPV and its clinical efficacy on positive hrHPV infectors. METHODS Huang San Ⅱ was used to the patients with cervical positive hrHPV infection. HC-Ⅱ technique was employed to detect the rate of negative conversion before treatment and 6 months later after treatment. We also estimated the varying serum levels of IFN-γ, TNF-α, IL-4, IL-10 by EI,ISA. RESULTS In our study, as the rate of negative conversion ascending , IL-4 and IL-10 levels were all significantly decreased after treatment, while IFN-γand TNF-α values increased spurtly. These variations above all had notable significancy. Further analysis showed there had some correlation between HPV and these factors. CONCLUSION Huang San Ⅱ may regulate Th1/Th2 im mune balance to cleanup HPV. It is of benefit to positive HPV infectors.

关 键 词：含砷复方中药 二黄散 hrHPV 感染者 

分 类 号：R285.6[医药卫生—中药学]