头孢哌酮中间体7-TMCA盐酸盐合成工艺的改进  

The Improvement of Synthetic Process for the Cefoperzaone Intermediate—7-TMCA.HCl

作　　者：高晓荣[1] 李俊波[2] 魏文珑[3] 常宏宏[3] 

机构地区：[1]太原科技大学化学与生物工程学院,太原030021 [2]长治医学院药学系化学教研室,山西长治046000 [3]太原理工大学化学化工学院,太原030024

出　　处：《中国现代应用药学》2009年第10期832-834,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的对抗生素头孢哌酮中间体7-TMCA盐酸盐的合成方法进行改进。方法以1-甲基-5-巯基四氮唑和7-氨基头孢烷酸为原料,采用三氟化硼乙腈络合物催化合成7-TMCA盐酸盐,并通过均匀试验对合成工艺进行了优化。结果合成产物经熔点、IR确证,收率为92.0%。结论此方法收率高,产品纯度好,适合工业化生产。OBJECTIVE The synthetic method of the cefoperazone intermediate--7-TMCA-HCl was improved in the paper. METHODS 1-methyl-5-mercapto-tetrazole and 7-amino-cephalosporin acid （7-ACA） was used as raw material and acetonitrile-boron trifluoride complex was utilized as catalyst to synthesize 7-TMCA-HCl. At the same time the synthetic process was optimized by the uniform experiment method. RESULTS The product was identified by melting point and IR spectra, the yield can reach up to 92.0%, CONCLUSION The product was obtained with much higher yield and good purity. It was suitable for industrial applications.

关 键 词：头孢哌酮 7-TMCA盐酸盐 三氟化硼乙腈络合物 

分 类 号：TQ460.6[化学工程—制药化工]