小儿利咽康颗粒剂免疫调节作用的实验观察  

Experimental obsevation on immune regulation effect of Liyankang granule on children

作　　者：王实[1] 宋光熠[1] 张广新[1] 刘永林[1] 李开明[1] 

机构地区：[1]辽宁中医药大学职业技术学院医学基础部,沈阳110101

出　　处：《中国中西医结合儿科学》2009年第5期448-450,共3页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：目的观察小儿利咽康颗粒剂的免疫调节作用。方法采用大鼠腹腔注射羟甲基纤维素钠致炎诱发白细胞游走,涂抹二硝基氟苯诱导小鼠迟发型超敏反应,小鼠尾静脉注射胶体碳悬液,腹腔注射10%羊红细胞免疫小鼠,观察小儿利咽康颗粒剂对羟甲基纤维素钠致炎诱发白细胞游走的抑制作用,对二硝基氟苯诱导小鼠迟发型超敏反应、对小鼠血中碳粒清除速度、对小鼠血清凝集素的影响。结果小儿利咽康颗粒剂可明显抑制白细胞游走作用,对二硝基氟苯致小鼠迟发型超敏反应有明显的抑制作用,对小鼠血中碳粒清除速度和小鼠血清凝集素的影响不明显。结论小儿利咽康颗粒剂具有一定的免疫调节作用。Objective To observe immune regulation effect of Liyankang granule on children. Methods The present study has been carried out using NaCMC injected into the mice＇s abdominal cavity to cause inflammation and induce white blood cell migration,varnishing DNFB to induce mice＇s DTH, injecting colloid activated carbon suspension into mice＇s tail vein, with 10% of sheep RBC injected into the abdomen to immunize mice. We observed inhibitory function of Liyankang granule on NaCMC to cause inflammation and induce white blood cell migration, the effect of DNFB on inducing mice＇s DTH and the effect on clearance speed of carbon particle in mice＇s blood and serum agglution of mice. Results Liyankang granule for children could obviouly inhibit migration of white blood cells, having obvious effect on inhibiting DNFB to mice＇s DTH,but the effect on clearance speed of carbon particle in mice＇s blood and serum agglutinin of mice was not obvious. Conclusion Liyankang granule for children has certain immune regulation effect.

关 键 词：炎症 中草药/治疗 大鼠 Wistar 小鼠 动物 实验 

分 类 号：R285.5[医药卫生—中药学]