心脏型脂肪酸结合蛋白对急性心肌梗死早期诊断的临床价值研究  

Research on the clinical value of H-FABP in early diagnosis of acute myocardial infarction

作　　者：安晓华[1] 徐维家[1] 薛邦禄[2] 马红光[2] 

机构地区：[1]辽宁省大连市中心医院检验科,116003 [2]辽宁省大连市临床检验中心,116023

出　　处：《国际检验医学杂志》2009年第9期860-861,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨心脏型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AMI)早期诊断中的临床应用价值。方法将来本院的AMI疑似患者156例,按就诊时发病时间分为2组,分别在发病后0～3、3～6 h内同时检测H-FABP、肌钙蛋白T(cTnT)、肌酸激酶同工酶(CK-MB)。计算各项指标的灵敏度、特异性、准确度,并进行比较分析。结果H-FABP在发病0～3 h内诊断的灵敏度为70.7%,特异性为97.0%,准确度为82.4%,显著高于cTnT和CK-MB,差异有统计学意义(P<0.05)。在发病3～6 h内诊断的灵敏度为100.0%,显著高于cTnT,差异有统计学意义(P<0.05),特异性为92.6%,准确度为97.6%。结论H-FABP是AMI早期诊断最敏感的指标,具有非常重要的临床应用价值。Objective To study the clinical value of heart-type fatty acid-binding protein （H- FABP） in early diagnosis of acute myocardial infarction（AMI）. Methods Totally 156 patients who were suspicious to be AMI were divided into group A （0-3 h group） and group B （3-6 h group） according to the visit time. H-FABP,cardiac troponin T （cTnT） and cardiac troponin T （cTnT） ; Creatine kinase isoenzyme-MB （CK-MB） were simultaneously measured at different time-points. The sensitivity,specificity and accuracy of the markers were calculated and compared. Results The sensitivity, specificity and accuracy of H-FABP were all the highest among three tumor markers; the sensitivity within 3 hours was 70.7% ,higher than that of cTnT and CK-MB remarkably （P〈0.05） ; the specificity was 97.0% ; the accuracy was 82.4%, higher than that of cTnT and CK-MB remarkably （P〈0. 05）;while the sensitivity within 3-6 hours was 100.0% ,higher than that of cTnT remarkably （P〈0. 05） ; the specificity was 92.6% ; and the accuracy was 97.6%. Conclusion H-FABP is the most sensitive indicator for early diagnosis of AMI and is of very important value in clinical application.

关 键 词：脂肪酸结合蛋白质类 心肌梗死 肌钙蛋白T 肌酸激酶 同工酶类 

分 类 号：R542.22[医药卫生—心血管疾病]