实验性肺血栓栓塞症后静脉血浆前列环素的变化  

Variation of plasma level of prostaglandingI2 before and after experimental acute pulmonary thromboembolism of rabbits

作　　者：况红艳[1] 周正[2] 陈献亮[1] 张罗献[1] 马利军[1] 

机构地区：[1]河南省人民医院呼吸内科,郑州450003 [2]郑州大学第二附属医院呼吸内科

出　　处：《中国实用医刊》2009年第21期8-9,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨实验性家兔急性肺血栓栓塞症（PTE）后静脉血浆前列环素（PGI2）的变化及意义。方法利用热处理后的家兔自体血凝块制备急性PTE家兔模型，通过肺脏解剖和病理证实PTE，并动态观察血浆PGI2水平。结果急性PTE后，静脉血浆PGI2于栓塞术后30min即迅速升高，1h仍较高，此后急剧下降，1d时达最低，以后持续低水平并缓慢回升，7d和10d时仍低于栓塞前，但7d和10d时与术前相比差异无统计学意义（P〉0．05），其余与术前相比差异均有统计学意义（P〈0．01）。结论急性PTE后PGI，显著升高在发病中有重要作用。Objective To study the variation and significance of venous plasma level of prostaglandingI2 before and after experimental acute pulmonary thromboembolism （ PTE ） of rabbits. Methods Acute PTE models of rabbits were established with injection of autologous blood clot, then the regulation of thrombosis was explored at dissection and upon mi- croscopic examination after PTE. Moreover, the venous plasma level of prostaglandingI2 （ PGI2 ） was examined. Results Venous plasma level of PGI2 began to increase at, 30 min and continually increased at 60 min, then immediately decreased significantly to its minimum at 1 day, and maintain its low level while increase slowly after clots infusion. Conclusions The apparent variation of PGI2 plays an important role in the phase of PTE.

关 键 词：肺血栓栓塞症 前列环素 动物模型 

分 类 号：R563.5[医药卫生—呼吸系统] R734.2[医药卫生—内科学]