国产替罗非班对急诊冠状动脉介入治疗患者远期心功能的改善作用  

Remote Improvement Effect of China-made Tirofiban on Patients Undergone Emergency Percutaneous Coronary Intervention

作　　者：宋丹[1] 余志华[1] 熊辉[1] 鄢华[1] 刘华云[1] 彭剑[1] 陈国洪[1] 汪敏[1] 苏唏[1] 

机构地区：[1]武汉亚洲心脏病医院,武汉430022

出　　处：《内科急危重症杂志》2009年第5期238-239,251,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨急诊经皮冠状动脉介入治疗(PCI)中使用国产替罗非班(欣维宁)对患者的远期心功能影响。方法:回顾性分析急诊PCI治疗患者117例,按是否使用国产替罗非班分为治疗组(36例)和对照组(81例),随访1年,观察左室射血分数(LVEF)、左室舒张末期容积指数(LVEDVI)、左室收缩末期容积指数(LVESVI)。结果:两组一般情况、基础临床情况和造影、介入资料均无显著差异(P>0.05),且术后即刻TI MI3级血流获得两组相似(94.44%vs92.59%,P>0.05)。术后随访1月时,两组左室射血分数均较术前有明显改善,但治疗组改善更明显(47.89%vs41.75%,P<0.05);且治疗组左室舒张末期容积指数(73.49ml/m2vs82.77ml/m2,P<0.05)和收缩末期容积指数(42.86ml/m2vs53.52ml/m2,P<0.05)均较对照组明显下降。随访1年,两组心功能相比未见显著差异,但两组心功能较术后1月有明显改善。结论:急诊PCI术中使用国产替罗非班能明显改善患者PCI术后1月的心功能,而1年后这种获益不复存在。Objective： To investigate the remote effect of homemade tirofiban on cardiac function of patients undergone emergency percutaneous coronary intervention （PCI）. Methods：One hundred and seventeen patients underwent emergency PCI were divided into two groups： tirofiban treatment group （n = 36） and the control group （n = 81）. Left ventricular ejection fraction （LVEF）, left ventricular end-diastolic volume index （LVEDVI）, left ventricular end-systolic volume index （LVESVI） were assessed 1 year after PCL Results： There were no significant differences between two groups in basic clinical or angiographic characteristics before PCI （P〉0. 05）. The two groups had no difference in percentage of TIMI 3 flow achieved in IRAs after PCI （94. 44% vs 92.59G,P〉0. 05）. LEVF significantly improved at 1-month follow up in two groups, but it improved more pronounced in tirofiban treatment group（47. 89% vs 41.75%, P〈0. 05）. LVEDVI and LVSDVI were decreased significantly than those in control group（73. 49 ml/m2 vs 82.77 ml/m2, P〈0. 05; 42. 86 ml/m2 vs 53. 52 ml/m2 , P〈0. 05）. There was no significant difference between two groups on improvement of cardiac function at one year following, but heart function was dramatically improved compared with that at 1-month after PCI in both groups. Conclusions： Application of Chinamade tirofiban during emergency PCI in patients with acute myocardial infarction could improve heart function at 1 month after PCI, but this superiority can not maintain 1 year after PCI.

关 键 词：替罗非班 经皮冠状动脉介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病]