心肌梗塞合并糖尿病患者血管紧张素转换酶基因多态性分析  

Insertion/Deletion Polymorphism of the Angiotensin Convertion Enzyme Gene in Patients with Myocardial Infarction in Non Insulin Dependent Diabetes Mellitus

作　　者：姚晓苓[1] 汪家瑞[1] 孙惠玲[1] 邢维常[1] 苏文娟[1] 曹心民[1] 白丹[1] 

机构地区：[1]首都医科大学宣武医院内科

出　　处：《首都医科大学学报》1998年第4期331-334,共4页Journal of Capital Medical University

摘　　要：采用ＰＣＲ技术对４４例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者，３１例ＮＩＤＤＭ合并心肌梗塞（ＭＩ）患者及１３２例正常对照组的血管紧张素转换酶（ＡＣＥ）基因插入／缺失（Ｉ／Ｄ）多态进行探测。结果：ＮＩＤＤＭ合并ＭＩ组ＡＣＥ基因Ｉ／Ｄ多态中的缺失型（ＤＤ）频率（０．４２）明显高于ＮＩＤＤＭ组（０．１４，Ｐ＜０．０５）及正常对照组（０．１７，Ｐ＜０．０５），正常对照组与单纯ＮＩＤＤＭ组ＡＣＥ基因Ｉ／Ｄ多态基因型分布比例相近似。结果提示：ＮＩＤＤＭ的发生与ＡＣＥ基因Ｉ／Ｄ多态无关，ＡＣＥ基因多态中ＤＤ型是ＮＩＤＤＭ患者心肌梗塞发病的危险因素之一。A 287 bp I/D polymorphism in intro 16 of the ACE gene was determined by polymerse chain reaction in a study of 44 patients with NIDDM, 31 patients with MI in NIDDM, and 132 healthy subjects without myocardial infarction and NIDDM. The result was that the frequencies of DD genetype among the NIDDM (0.14) was similar to that of the healthy control subjects (0.17). The freguencies of DD genetype were higher among the MI in NIDDM group (0.42) than among the healthy control subjects (0.17, P <0.05)and among the NIDDM group (0.14, P <0.05). It suggested that deletion polymorphism of the ACE gene may be a risk factor of MI in NIDDM in Chinese population.

关 键 词：多态性 心肌梗塞 糖尿病 NIDDM ACE基因 

分 类 号：R542.22[医药卫生—心血管疾病] R587.1[医药卫生—内科学]