2-乙氧基乙醇对小鼠睾丸和附睾毒性作用的病理形态学研究  

A Pathomorphological Study on Testes and Epididymides of Rats in 2 Ethoxyethanol induced Toxicity

作　　者：唐小奈[1] 李泳[1] 吴小青[1] 高星[2] 刘建中[2] 

机构地区：[1]首都医科大学附属北京红十字朝阳医院病理科 [2]北京市劳动卫生职业病防治研究所

出　　处：《首都医科大学学报》1998年第4期345-348,共4页Journal of Capital Medical University

摘　　要：为研究２乙氧基乙醇（ＥＥ）对睾丸和附睾的毒性作用，制成小鼠ＥＥ染毒模型，观察其睾丸、附睾病理形态学改变。结果发现ＥＥ引起小鼠睾丸初级精母细胞退变坏死、精细胞分化障碍、精子形成减少、附睾管上皮退变，同时可见睾丸间质细胞增生。以上病变随药量增多而加重，说明ＥＥ对小鼠睾丸和附睾具有病理性损伤作用。结果提示：对职业性接触ＥＥ者，应定期进行精子功能检查，并采取适当的防治措施。Forty adult Kunming rats were used and divided into four groups, i.e. normal control group and three experimental 2 ethoxyethanol(EE) induced groups. The results of pathomorphological observation of testes in EE groups showed: Primary spermatocytes degenerated and necrosed, spermatids differentiation ceased, the number of mature spermatozoon diminished. The epithe lium cells had degenerated and the ductal wall of epididymis became thinner. The stroma cells of the testis proliferated. The above lessions were aggrevated as the dose of EE increased. The fact indicated that EE had pathological effects on testis and epididymis. It was recommended that regular examination of the function of spermatosome should performed on those who professionally exposed to EE, and proper protective action should be adopted.

关 键 词：乙氧基乙醇 睾丸 附睾 病理形态学 毒性作用 

分 类 号：R135.1[医药卫生—劳动卫生] R994.3[医药卫生—公共卫生与预防医学]