西安地区供血员中HLA-A2抗原分布和HCV感染关系的初步研究  

AN INITIAL STUDY ON THE RELATIONSHIP BETWEEN HCV INFECTION AND HLA-A2 ANTIGEN DISTRIBUTION IN DONORS IN XI′AN

作　　者：李长秦[1,2] 周红超[1,2] 徐德忠[1,2] 董菁 张鹏[1,2] 张景霞 

机构地区：[1]第四军医大学流行病学教研室 [2]陕西中医学院温病教研室

出　　处：《解放军预防医学杂志》1998年第6期415-417,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：国家自然科学基金

摘　　要：用对比研究的方法分析了１５例感染丙型肝炎病毒（ＨＣＶ）的供血员（病例组）和１５例健康供血员（对照组）中ＨＬＡⅠ类抗原分布频率。结果发现，病例组中，ＨＬＡ－Ａ２、Ａ１１、Ｂ４０、Ｂ１５的抗原频率分别为２６．６７％、３３．３３％、６．６７％、２０．００％。对照组中ＨＬＡ－Ａ２、Ａ１１、Ｂ４０、Ｂ１５的抗原频率分别为７３．３３％、４０．００％、６．６７％、６．６７％，ＨＬＡ－Ａ２抗原频率在病例组和对照组之间存在显著差异（Ｐ＜０．０５）。We have comparatively analyzed the frequency of HLA Ⅰ antigens in 15 donors(case group) infected by HCV and 15 health donors (control group). The results show that the frequencies of HLA-A2, A11, B40, B15 are 26.67%, 33.33%, 6.67%, 20.00% in case group and 73.33%, 40.00%, 6.67%, 6.67% in control group. The difference of HLA-A2 frequency in case group and control group is significant (P<0.05).It indicates that HLA-A2 antigen may be related to HCV infection and carrier status in donor population in Xi ,an.

关 键 词：丙型肝炎病毒 HLA 抗原 献血员 

分 类 号：R512.63[医药卫生—内科学]