表皮生长因子对人绒毛膜促性腺素诱导的黄体细胞孕酮生成的影响  

Effect of EGF on hCG induced Progesterone Production of Luteal Cells in Vitro

作　　者：刘家慧[1,2,3] 张桂华[1,2,3] 彭如心[1,2,3] 王启发[1,2,3] 程治平[1,2,3] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所 [2]齐齐哈尔医学院 [3]哈尔滨医科大学生理教研室

出　　处：《基础医学与临床》1998年第6期27-32,共6页Basic and Clinical Medicine

摘　　要：本实验用体外培养的大鼠黄体细胞，研究了ＥＧＦ对ｈＣＧ和ＰＫＡ系统激活剂诱导的黄体细胞孕酮与ｃＡＭＰ生成的影响。结果表明ＥＧＦ、ｈＣＧ、ＣＴ、ＰＴ、ＦＳＫ都能刺激基础孕酮和ｃＡＭＰ生成，但ＥＧＦ对ｈＣＧ、ＣＴ、ＰＴ、ＦＳＫ、ｄｂｃＡＭＰ诱导的孕酮生成是抑制作用，而对它们诱导的ｃＡＭＰ生成却是促进作用。研究表明ＥＧＦ对卵巢功能具有调节作用。In this experiment the effects of EGF on hCG and PKA agonists induced production of progesterone and cAMP in cultured rat luteal cells were studied.The results showed that EGF,hCG,CT,PT and FSK by themselves stimulated the production of basal progesterone and cAMP,but EGF inhibited hCG ,CT ,PT ,FSK and dbcAMP induced progesterone production in the culture.On the contrary,EGF enhanced cAMP production induced by these factors.The study suggests that EGF may play a regulating role in luteal cell progesterone production by inhibition of hCG/LH induced progesterone production.However,this effect is not through inhibiting protein G cAMP pathway.

关 键 词：表皮生长因子 孕酮生成 CAMP 黄体细胞 HCG 

分 类 号：Q516[生物学—生物化学] Q579.1