阿维A对寻常性银屑病患者血清IL-18的影响  

Affection of acitretin on serum IL-18 in the patients with psoriasis vulgaris

作　　者：林玲[1] 罗权[1] 刘玉梅[1] 何玉清[1] 周欣[1] 张锡宝[1] 

机构地区：[1]广东省广州市皮肤病防治所,广东广州510095

出　　处：《海南医学》2009年第11期4-5,共2页Hainan Medical Journal

基　　金：广东省自然科学基金(编号:07001961);广州市医药卫生科研项目(编号:2007-YB-231)

摘　　要：目的研究IL-18在寻常性银屑病发病中的作用及阿维A对其的调节作用,进一步探讨阿维A治疗银屑病的机制。方法应用双抗体夹心酶联免疫吸附法(ELISA)检测30例寻常性银屑病患者经阿维A治疗前后外周血IL-18的水平变化。结果寻常性银屑病患者经阿维A治疗前的血清中IL-18的水平显著高于治疗后及正常人对照组;治疗后血清中IL-18水平较治疗前显著下降(P<0.05)。结论IL-18在寻常性银屑病致病中起重要作用;阿维A治疗银屑病的机制可能是通过抑制IL-18的分泌而达到治疗作用。Objective To investigate the regulation of aeitretin on IL - 18 in the patients with psoriasis vulgaffs as well as explore its mechanism. Methods Levels of IL - 18 in sera were measured by double antibody sandwich enzyme - linked immunosorbent assay （ ELISA ） in 30 patients with psoriasis vulgaffs before and after treatment with acitretin. Results Compared with those in normal controls, the serum levels of IL - 18 in the patients with psoriasis vulgaris were significantly higher （ P 〈 0.05 ） ; after the treatment with acitretin, the serum levels of IL - 18 were statistiely decreased（ P 〈 0.05 ）. Conclusion IL - 18 plays an important role in the pathogenesis of psoriasis. It is indicated that inhibiting the secretion of IL - 18 may be involved in the mechanism of aeitretin to treat psoriasis vulgaris.

关 键 词：阿维A 银屑病 白细胞介素18 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]