盐酸塞利洛尔合成工艺改进  

Improved synthesis of celiprolol hydrochloride

作　　者：王礼琛[1] 任进知[1] 韦万武 刘春河[1] 

机构地区：[1]中国药科大学有机化学教研室,南京210009

出　　处：《中国现代应用药学》1998年第6期35-36,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的:合成盐酸塞利洛尔,并进行工艺改进。方法:革除溴化反应,对醚化反应进行了优化。结果:使合成路线缩短一步,醚化收率比文献值提高20％以上。结论:该路线较适合于工业化生产。OBJECTIVE: Synthesis of celiprolol hydrochloride and the improvement of the process. METHODS:Abolishing of brominating step and optimizing of etherifying reaction. RESULTS: Synthetic route was shorten by one step, the yield of etherification increased by 20% or more as compared with the yield in literature.CONCLUSION:The route is more suitable for manufacture.

关 键 词：塞利洛尔 盐酸 合成工艺 对氨基苯乙醚 

分 类 号：TQ463.4[化学工程—制药化工]