川续断总生物碱对妊娠大鼠子宫的抗致痉及抗流产作用  

Antispasmodic and Antiabortifacient Effects of Total Alkaloids from Dipsacus asperoides on Pregnant Rats

作　　者：龚晓健[1] 季晖[1] 王青 吴知行[2] 刘国卿[1] 

机构地区：[1]中国药科大学药理教研室,南京21009 [2]中国药科大学天然药物化学教研室,南京21009

出　　处：《中国药科大学学报》1998年第6期459-461,共3页Journal of China Pharmaceutical University

基　　金：国家自然科学基金

摘　　要：本研究表明川续断总生物碱能显著抑制妊娠大鼠在体子宫平滑肌的自发收缩活动，降低其收缩幅度和张力；对抗0．25U·kg－1催产素诱发的妊娠大鼠在体子宫收缩幅度和张力的增加；并具有对抗大鼠摘除卵巢后导致的流产作用。Total alkaloids extracted from Dipsacus asperoides markedly inhibited the spontaneous contraction of pregnant rat uterus in vivo,and suppressed the increase of intensity,tonicity and frequency induced by Oxytoxin (0. 25 U/kg) in pregnant rat uterus in vivo. Total alkaloids also antagnized abortion of rats induced by removal of ovary.

关 键 词：川续断 总生物碱 在体子宫 实验药理 抗流产作用 

分 类 号：R285.5[医药卫生—中药学] R271.942.1[医药卫生—中医学]