强肾壮骨分散片制备工艺的初步研究  

Preliminary Research of Zhuanggu Dispersible Tablets Producing Technology

作　　者：全红[1] 曲倩雯[1] 郭春秋[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040

出　　处：《中国医药导刊》2009年第10期1765-1766,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:强肾壮骨处方由骨碎补,淫羊藿,牛膝,牡蛎四位中药组成。本文以此方为模型,探索强肾壮骨分散片的制备方法。方法:以药粉含量50%为前提,为了保证分散片崩解时限3min,联用崩解剂并通过正交试验优化处方。结果:得出分散片最终处方为药物提取物50%,微晶纤维素(MCC)为药粉量20%,淀粉为药粉量20%,交联聚维酮(PVPP)为药粉量10%。结论:采取正交试验优化此制备工艺可行。Objeetive：BushenZhuanggu prescription includes Davallia mariesii Moore ex Bak, Epimedium brevieornum Maxim, Achyranthes bidentata BL., concha ostreae ,four components of Chinese medicine, this article using this preseriptinn as a model to explore the producing method of physical Zhuanggu dispersible tablet. Methods： 50 % powder content of the premise in order to guarantee the dispersible tablets Disintegration 3 minutes, combined with disintegrants and opttimized by orthogonal test prescription. Results： To obtain the dispersible tablet prescription drugs eventually extract 50 %, MCC for 20 % of the volume of powder, starch powder volume to 20 %, PVPP powder volume to 10 %. Conclusion： Take the ortlaogonal test to optimize the preparation of feasibility.

关 键 词：强肾壮骨分散片 正交试验 崩解时跟 制备工艺 

分 类 号：R283[医药卫生—中药学]