酮洛芬的脊髓镇痛作用及其机制  

Spinal analgesic effect and mechanism of ketoprofen, a NSAID

作　　者：王瑜[1] 章家胜[1] 董六一[1] 岑德意[1] 方明[1] 江勤[1] 宋必卫[1] 

机构地区：[1]安徽医科大学药理学教研室

出　　处：《中国药理学通报》1998年第3期251-253,共3页Chinese Pharmacological Bulletin

基　　金：安徽省教育委员会资助

摘　　要：目的研究酮洛芬的脊髓镇痛作用及作用机制。方法采用温浴法、热板法观察动物痛阈变化。结果鞘内注射（ｉｔｈ）酮洛芬１．６～３．２ｍｇ·ｋｇ－１具有明显镇痛作用，全身用药需１６ｍｇ·ｋｇ－１才具有同等镇痛效应。ｉｔｈ与ｉｐ药物有效剂量比为１∶１０。ｉｔｈ用药，作用可被ｉｐ利血平、ｓｃ哌唑嗪、育亨宾阻滞。结论酮洛芬具有脊髓镇痛作用。AIM Spinal analgesia and mechanism of ketoprofen in mice were studied. METHODS The tail immersion test and hot plate test were used to observe variations of pain threshold of mice. RESULTS Dosedependent analgesia was observed following intrathecal administration of KPF 16 or 32 mg·kg-1,the ratio of effective doses for intrathecal/systemic (ip ) KPF was 1∶10, The analgesia of intrathecal KPF 16 mg·kg-1 was abolished when the animals were pretreated with reserpine (3 mg·kg-1,ip); α1 receptor antagonist prazosin (10 mg·kg-1, sc) or α2 receptor antagonist yohinbine (4 mg·kg-1, sc). CONCLUSIONS KPF has noradrenergic nerve mediated spinal analgesia.

关 键 词：酮洛芬 非甾体抗炎药 脊髓镇痛 药理 

分 类 号：R971.1[医药卫生—药品]