吡啶-2,6(1H,3H)二酮生物碱对ADP、AA、Collagen诱导的兔血小板聚集的影响  

Inhibitory effect of pyridine2, 6(1H,3H)dione alkaloids on rabbit platelet aggregation induced by ADP, AA and Collagen

作　　者：杨俊旺[1] 梁永录 李文广[1] 刘茵 张蜜过 吴勇杰 石建功 汪汉卿 

机构地区：[1]解放军兰州医学高等专科学校药理学教研室

出　　处：《中国药理学通报》1998年第1期24-26,共3页Chinese Pharmacological Bulletin

基　　金：中国科学院基础研究局"九五"预研课题;兰州军区后勤部课题

摘　　要：目的观察吡啶－２，６（１Ｈ，３Ｈ）二酮生物碱（ＳＨ１）对ＡＤＰ、ＡＡ、Ｃｏｌｌａｇｅｎ诱导的兔血小板聚集的影响。方法用比浊法测定了ＳＨ１体外对兔血小板聚集的影响。结果ＳＨ１对３种诱导剂的最大抑制率分别为６２．１６％、４５．２５％、５３．６７％。大剂量组明显加快ＡＤＰ诱导的兔血小板聚集后的解聚速度。ＳＨ１显著延长Ｃｏｌａｇｅｎ的诱导起聚时间。结论ＳＨ１０．８～４．０ｍｍｏｌＬ－１范围内明显抑制ＡＡ、ＡＤＰ、Ｃｏｌａ－ｇｅｎ诱导的兔血小板聚集。其抑制作用有明显的量效关系。其机制待进一步研究。AIM To investigate the effect of pyridine2,6(1H,3H)dione alkaloids SH1 (from speranskia tuberculata) on rabbit platelet aggregation induced by ADP, AA and Collagen. METHODS Platelets aggregation induced by arachidonic acid (AA) or adenosine diphosphate (ADP) or Collagen were studied by turbidimetry and radioimmunoassay in rabbits blood, in vitro. RESULTS SH1 08, 10, 20 and 40 mmol·L-1 inhibited platelet aggregation. The inhibition by SH1 was dosedependent: 234%￣622%(ADPinduced), 116%￣453%(AAincuced), 18%￣537%(COLinduced), in vitro. CONCLUSION SH1 and Aspirin could inhibit rabbits platelet aggregation induced by ADP, AA and COL.

关 键 词：吡啶 二酮生物碱 透骨草 血小板聚集 

分 类 号：R285.5[医药卫生—中药学] R973.2[医药卫生—中医学]