人参二醇组皂甙对大鼠皮层神经元钙通道的影响  

Effect of panaxadiol saponins on calcium channels in cortical neurons of rats

作　　者：开丽[1] 王中峰[1] 肖家思[1] 

机构地区：[1]第三军医大学基础部药理教研室

出　　处：《中国药理学通报》1998年第1期53-56,共4页Chinese Pharmacological Bulletin

摘　　要：目的研究人参二醇组皂甙（ＰＤＳ）对大鼠大脑皮层神经元膜Ｌ－型钙通道单通道电活动的影响。方法急性分离大鼠皮层神经元和细胞贴附膜片钳技术。结果ＰＤＳ（１．５ｇＬ－１）可明显缩短大鼠皮层神经元Ｌ－型钙通道的平均开放时间，延长其平均关闭时间，降低其开放概率，而对该通道的电流幅值无明显影响，其作用与经典钙通道阻断剂ｖｅｒａ－ｐａｍｉｌ相似但较弱。结论ＰＤＳ对大鼠皮层神经元Ｌ－型通道有明显阻滞作用。AIM To study the effects of panaxadiol saponins (PDS) on the single channel activity of Ltype calcium channel in cortical neurons of rats. METHODS Using patch clamp technique of cellattached configuration and acutely isolated cortical neurons of wistar rats. RESULTS PDS (15 g·L-1) shortened the open time of Ltype calcium channel, prolonged the close time, decreased the openstate probability, but exerted no effects on the amplitude of ionic current flow through the Ca2+ channel. The actions of PDS were similar to those of verapamil, a potent calcium channel blocker, but the effects of PDS were less than those of verapamil. CONCLUSION PDS has the blockade effects on the Ltype calcium channel in cortical neurons of rats.

关 键 词：人参二醇组皂甙 皮层神经元 钙通道 

分 类 号：R285.5[医药卫生—中药学] R338.25[医药卫生—中医学]