幽门螺杆菌HSP60与急性冠脉综合征及病变程度关系的研究  

Association between helicobacter pylori-heat shock protein60 and acute coronary syndrome

作　　者：王广[1] 王育珊[1] 陈星海[1] 

机构地区：[1]吉林大学第二医院急救医学科,吉林长春130041

出　　处：《中国实验诊断学》2009年第10期1397-1398,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨幽门螺杆菌热休克蛋白60(HSP60)与急性冠脉综合征及其病变程度的相关性。方法应用酶联免疫吸附法测定62例冠心病患者HSP60含量,根据冠状动脉造影将其分为1支2、支、3支病变组,并与24例非冠心病者对照比较。采用免疫散射比浊法测定高敏C反应蛋白。结果对照组与ACS组HSP60含量水平差异有显著性;3支病变组HSP60水平与单支及2支病变组比较显著增加,2支病变组较单支病变组有升高趋势,有统计学意义(P<0.05)。ACS组高敏C反应蛋白(hsCRP)较对照组有显著增加(P<0.05)。结论hsCRP水平增高与ACS有关。HSP60含量增高不仅与ACS有关,还与冠状动脉病变程度有关。Objective To investigate the possible association between helicobacter pylori-heat shock protein60 and acute coronary syndrome（ACS）.Methods heat shock protein60 was assessed by ELISA in 62 patients with ACS and 24 controls.We measured plasma CRP levels by immuno-nehelomitery.Results Prevalence of heat shock protein60 was higher in ACS patients than in controls（P〈0.05）.The patients of 3-lesions group also had a higher prevalence of HSP60 than 1-lesion and 2-lesions group.HSP60 was significantly higher in 2-lesions than 1-lesion group（P〈0.05）.Movrover,Prevalence of hsCRP was higher in ACS patients than in controls（P〈0.05）.Conclusion The association between increased hsCRP and ACS was close.HSP60 seemed not only to be related to ACS but also to be more related to pathological changes of coronary artery.

关 键 词：幽门螺杆菌 热休克蛋白60 急性冠脉综合征 高敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]