肝硬化肝功能分级的超声造影定量分析  

Quantitative analysis of liver function with contrast enhanced ultrasonography of liver cirrhosis

作　　者：郭梦安[1,2] 廖锦堂[1] 

机构地区：[1]中南大学湘雅医院超声影像科,湖南长沙410008 [2]益阳医学高等专科学校附属医院内科,湖南益阳413000

出　　处：《中国医学影像技术》2009年第10期1824-1826,共3页Chinese Journal of Medical Imaging Technology

基　　金：湖南省教育厅科研项目资助课题(2005B10401040)

摘　　要：目的探讨超声造影(CEUS)定量指标与肝硬化肝功能分级的相关性。方法病例组为慢性乙型肝炎后肝硬化患者75例,按肝功能分级A、B、C级分为A、B、C三组,每组各25例;对照组健康人20名。测量右肝静脉内径(RHVD)、右肝静脉频谱(RHVF),团注SonoVue1.2ml后,观察右肝动脉(RHA)和右肝静脉(RHV)的显影过程,分别记录右肝动脉内和右肝静脉内造影剂首次到达时间(HATT、HVTT),计算两者的差值即肝渡越时间(HTT),将所得结果进行统计学分析。结果与对照组比较,病例组RHVD明显减小、RHVF变为异常波,HVTT、HTT明显提前;HVTT、HTT随肝功能分级的严重性加重而明显提前,以HTT意义更大。结论CEUS定量分析对肝功能分级超声定性诊断具有一定的临床应用价值,其中以HTT意义更大。Objective To observe the corelation between quantitative index and the grade of the liver function with contrast-enhanced ultrasonography （CEUS） in hepatic cirrhosis. Methods Seventy-five patients of cirrhosis after HBV were di vided into 3 groups （each n=25） on the basis of the liver function by Child-pugh method, while 20 healthy subjects were enrolled in the control group. The inner diameter and Doppler spectrum of right hepatic vein （RHVD, RHVF） were measured. After intravenous bolus injection 1.2 ml SonoVue, RHA and RHV were observed continually on real time, hepatic artery transit time （HATT） and hepatic vein transit time （HVTT） were recorded, then HTTs were calculated. Results In hepatic cirrhosis groups, RHVD decreased remarkably, RHVF was abnormal, HVTT and HTT were obviously shorter, and HTTs were shortened significantly. Conclusion CEUS may play an important role in qualitative evaluation of liver func tion, and HTT is more valuable than HVTT.

关 键 词：肝硬化 肝功能 超声检查 

分 类 号：R445.1[医药卫生—影像医学与核医学] R575.2[医药卫生—诊断学]