磁共振扩散加权成像在评价前列腺癌骨转移病灶内分泌治疗效果中的价值  

Diffusion weighted imaging in the evaluation of therapeutic effect of endocrine for prostate cancer with bone metastases

作　　者：王鹤[1,2] 王霄英[1,2] 李飞宇[1,2] 郭雪梅[1,2] 蒋学祥[1,2] 

机构地区：[1]北京大学第一医院医学影像科 [2]北京大学前沿交叉学科研究院功能成像研究中心,北京100034

出　　处：《中国医学影像技术》2009年第10期1833-1836,共4页Chinese Journal of Medical Imaging Technology

基　　金：首都医学发展基金(2007-2006);2007年度高等学校博士学科点专项科研基金新教师项目(20070001745)

摘　　要：目的探讨磁共振扩散加权成像对前列腺癌骨转移病灶内分泌治疗效果的评价。方法40例临床确诊为前列腺癌骨转移的连续病例接受扩散加权成像序列(DWI)检查:治疗组17例,为前列腺癌骨转移经过内分泌治疗后患者;对照组23例,均为前列腺癌伴骨转移的初诊病例,未经过任何治疗。治疗组所有患者为治疗有效病例,无临床复发表现。在b=0及b=800s/mm2的DWI中,测量骨转移病灶、正常肌肉(右侧臀大肌)、正常骨(通常取右侧股骨头)及充盈膀胱的ADC值。应用非参数独立样本检验比较两组患者骨转移病灶的ADC值,P<0.05为差异有统计学意义。结果治疗组骨转移灶ADC值为(1.10±0.50)10-3mm2/s,对照组骨转移灶ADC值为(1.12±0.30)10-3mm2/s(P>0.05)。结论MRDWI不能反映前列腺癌骨转移灶内分泌治疗的效果。Objective To evaluate the therapeutic effect of endocrine for prostate cancer with bone metastases with MR diffusion-weighted imaging （DWl）. Methods Forty patients with bone metastases from prostate cancer were examined with DWI. Seventeen patients underwent endocrine therapy were recruited as the test group, the other 23 were regarded as the control group. There was no relapse of the metastases according to clinical diagnosis in the test group. DWI sequences were based on steady-state free precession with b value （800 s/mm^2）. After identifying the metastasis according to the TlWI and T2WI, ROIs were marked at the metastases, normal muscle, normal bone and bladder on DWI, and the ADC values of the ROIs were calculated respectively. Non-parameter two independent samples test was applicated to compare the ADC values of the metastases between the two groups. Results ADC values of the bone metastases were （1. 10±0.50） × 10^-3mm^2/s in the test group and （1.12±0. 30）× 10^-3 mm^2/s in the control group （P〉0.05）. Conclusion MR DWl shows no help in evaluating the therapeutic effect of endocrine for prostate cancer with bone metastases.

关 键 词：前列腺肿瘤 骨转移 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R73-37[医药卫生—诊断学]