胃间质瘤的临床病理特征和预后相关因素分析  

Gastrointestinal stromal tumors of the stomach

作　　者：赵天锁[1] 李慧锴[1] 王秀超[1] 任贺[1] 郝继辉[1] 

机构地区：[1]天津医科大学附属肿瘤医院腹部肿瘤科天津市肿瘤防治重点实验室,300060

出　　处：《中华普通外科杂志》2009年第9期689-691,共3页Chinese Journal of General Surgery

摘　　要：目的探讨胃间质瘤的临床病理特征及预后相关因素。方法回顾性分析1996年3月至2008年3月间天津医科大学附属肿瘤医院121例行手术切除治疗的胃间质瘤患者的临床资料，分别对性别、年龄、肿瘤大小及组织学类型等因素进行预后分析。结果本组121例患者中位生仔期为73．2个月，术后1年、3年及5年总生存率分别为82％、59％和50％，术后1年、3年、5年无瘤生存率分别为65％、46％干u33％。单因素分析显示，性别（P=0．000）、肿瘤大小（P=0．000）及累及脏器（P=0．000）是影响预后的因素；多因素分析则显示，性别（P=0．000）、肿瘤大小（P=0．000）及累及脏器足影响预后的独讧因素。结论胃间质瘤中的男性、肿瘤直径〉10cm及累及周围脏器的患者颅后较盖。Objective To investigate the clinical characteristics of gastrointestinal stromal tumor （GIST） of the stomach and to analyze the corresponding prognostic factors. Methods We retrospectively reviewed the clinical data of 121 patients in our hospital from March 1996 to March 2008. Gender,age,tumor size and histological type were analyzed. Results For these 121 cases the median survival time is 73.2 months. The overall 1-,3-,and 5-year survival rates were 82% , 59% and 50% respectively. The tumor-free survival rates for 1-,3-,and 5-yeas were 65%, 46% and 33% respectively. Cox univariate analysis revealed that gender,tumor size ,organ involvement and recurrence were factors impacting prognosis. Cox multivariate analysis revealed that gender, tumor size, organ involvement, recurrence were prognostic factors for gastric GIST. Conclusions Male sex,tumor size （ 〉 10 era） and involvement of organ were independent indicators for a poor prognosis in patients with primary malignant gastric GIST.

关 键 词：胃肠道间质肿瘤 病理学 临床 预后 

分 类 号：R686[医药卫生—骨科学]