阿托品微量泵持续静脉推注在治疗急性有机磷农药中毒中的临床应用  

Study on Atropine Injection by Micropump in Acute Organophosphorus Pesticide Poisoning Treatment

作　　者：钟志越[1] 何岱昆[1] 黎俊[1] 张宝成[1] 申捷[1] 

机构地区：[1]复旦大学附属金山医院化学伤害救治中心ICU,上海200540

出　　处：《中国临床医学》2009年第5期816-818,共3页Chinese Journal of Clinical Medicine

基　　金：上海市公共卫生重点科学建设项目资助(08GWZX0404)

摘　　要：目的:探讨阿托品微量泵持续静脉推注在治疗急性有机磷农药中毒中的临床疗效。方法:将51例急性中重度有机磷农药中毒患者随机分成观察组和对照组。观察组:采用微量注射泵持续静脉推注阿托品;对照组:采用常规间断分次按时静脉推注阿托品。其他抢救措施及药物应用相同,观察比较两组的临床疗效。结果:观察组阿托品化时间、阿托品剂量及反跳和中毒的发生率与对照组相比较明显减少,治愈率为96.2%高于对照组的76.0%,差异有统计学意义(P<0.05)。结论:阿托品微量泵持续静脉推注治疗急性有机磷中毒用药方法简便,易于观察和调整阿托品用量,能缩短阿托品化时间,减少阿托品中毒及反跳的发生率,提高抢救成功率。Objective：Study on the clinical effect of atropine injection by micropump in acute organophosphorus pesticide poisoning treatment. Methods： Fifty-one patients of acute organophosphorus pesticide poisoning were divided randomly into the study and control groups. Atropine was continuously injected by micropump in the study group, while atropine was routinely injected at different time on time. Other management and medicine application were the same in the two groups, study on the clinical effect of the two groups. Results： The accumulating dosage of atropine and the time of atropinization in the study group were lower than those of the control group（P〈0.05 ,P〈0. 01 ）. The curative rate was 96.2% in the study group,higher than the curative rate of 76.0% in the control group（P〈0. 05）. Conclusion： There are several advantage of continuous atropine injection by micropump in acute organophosphorus pesticide poisoning treatment. It is easy to observe,adjust the dosage of atro- pine,promote the rescue rate ,decrease the occurrence of atropism and the time of atropinization. The atropine injection by mi- cropump in acute organophosphorus pesticide poisoning treatment has proved to be a fine medication.

关 键 词：阿托品 微量泵注射 有机磷农药中毒 

分 类 号：R595.4[医药卫生—内科学]