反复自然流产的免疫抗体研究  

Study on immunity antibodies of recurrent spontaneous abortion

作　　者：孙春玲[1] 刘玉萍[2] 张宏颜 

机构地区：[1]白城师范学院生物系,吉林白城137000 [2]吉林大学第三医院妇产科 [3]白城医学高等专科学校附属医院妇产科

出　　处：《中国妇幼保健》2009年第31期4460-4461,共2页Maternal and Child Health Care of China

基　　金：吉林省科委资助项目〔1999527〕

摘　　要：目的:探讨反复自然流产与免疫抗体的关系。方法:采用ELISA法检测30例不明原因反复自然流产(流产组)患者血清抗精子抗体(AsAb)、抗子宫内膜抗体(EmAb)、抗卵巢抗体(AovAb)、抗心磷脂抗体(AcAb)和抗绒毛膜促性腺激素抗体(AhcGAb)的含量,以非妊娠期健康育龄妇女30名为对照组。结果:流产组AsAb阳性率为26.94%,EmAb阳性率为43.10%,AovAb阳性率为31.26%,AcAb阳性率为47.03%,AhcGAb阳性率为49.01%,均明显高于对照组。结论:上述5种免疫抗体可干扰卵的发育成熟、排卵、受精、胚泡着床和胚胎发育等过程,与不明原因反复自然流产关系密切。Objective： To study the relationship between immunity antibodies and recurrent spontaneous abortion. Methods： Thirty patients with recurrent spontaneous abortion were selected as abortion group, and thirty healthy women were selected as control group. The levels of antisperm antibody （AsAb） , endometriat antibody （ EmAb）, anti - ovary, antibody （ AovAb）, antieardiolipin antibody （AeAb） and anti -human chorionic gonadotropin antibody （AhcGAb） in serum were detected by ELISA. Results： In abortion group the positive rates were AsAb 26. 67% , EmAb 43.33% , AovAb 30. 00% , AcAb 46. 67% and AhcGAb 50. 00%. There was significant difference in detection rate of the five immunity antibodies between 2 groups. Conclusion ： It is suggested that the five immunity antibodies may affect ovum maturity, ovulation, fertilization, fertilized ovum embedding and fetal development, which are related to female infertility.

关 键 词：自然流产 免疫抗体 抗精子抗体 抗子宫内膜抗体 抗卵巢抗体 抗心磷脂抗体 抗绒毛膜促性腺激素抗体 

分 类 号：R714.21[医药卫生—妇产科学]