盐酸普萘洛尔缓释片的研究  

Study on propranolol hydrochlororide sustaind-release tablets

作　　者：王明森[1] 王洪光[1] 

机构地区：[1]青岛科技大学,山东青岛266042

出　　处：《西北药学杂志》2009年第6期469-471,共3页Northwest Pharmaceutical Journal

摘　　要：目的研究盐酸普萘洛尔缓释片的处方工艺和体外释放度。方法通过考察影响释放度的主要因素,筛选处方中的关键阻滞剂和崩解剂,优化处方的制备工艺。结果新处方和优化工艺制备的盐酸普萘洛尔缓释片符合药典要求,重现性较好,稳定性较好。结论实验所得的处方和工艺可以制备性能优良的普萘洛尔缓释片。Objective To prepare the propranolol hydrochlororide sustaind-release tablets. Methods Main additives such as retarding agent and disintegration were selected. The preparation procedure of propranolol hydrochlororide sustaind-release tablets was optimized by investigating the factors of release. Results The release met the requirement of sustained-release tablets, and showed good reproducibility and stability. Conclusion The preparation and formula presented in the paper appear a promising future in the preparation of propranolol sustained-release tablets .

关 键 词：溶蚀性骨架缓释片 盐酸普萘洛尔 释放度 

分 类 号：R944[医药卫生—药剂学]