短期苯接触对鞋厂工人T淋巴细胞亚群影响的研究  

STUDY ON THE IMPACT OF SHORT-TERM BENZENE EXPOSURE ON T LYMPHOCYTE SUBSETS IN SHOE FACTORY WORKERS

作　　者：钱庆增[1] 刘英莉[1] 王茜[1] 白玉萍[1] 李清钊[1] 关维俊[1] 

机构地区：[1]华北煤炭医学院预防医学系国家煤炭煤矿卫生与安全重点实验室,唐山063000

出　　处：《现代预防医学》2009年第21期4024-4026,4029,共4页Modern Preventive Medicine

基　　金：科技部社会公益研究专项项目(2005DE101439)

摘　　要：[目的]探讨短时期内苯对鞋厂工人机体免疫系统的影响。[方法]采用单克隆抗体APAAP法,对50例鞋厂工人进行T淋巴细胞亚群检测。[结果]与健康非苯接触人员相比较,短期苯接触工人T淋巴细胞亚群CD4值+无明显变化,差异无统计学意义(P﹥0.05);而CD3及CD8值显著增加,差异有统计学意义(P﹤0.01);CD4/CD8比值++++显著降低,差异有统计学意义(P﹤0.01)。短期苯接触工人在工龄、车间、性别方面相互比较时,T淋巴细胞亚群CD3、+CD4、CD8及CD4/CD8比值均无明显变化,差异无统计学意义(P﹥0.05);而分别与对照组相比较时短期苯接触工人T++++淋巴细胞亚群只有CD4值无明显变化,差异无统计学意义(P﹥0.05);CD3及CD8值均显著增加,差异有统计学意义(P+++﹤0.01);CD4/CD8比值均显著降低,差异有统计学意义(P﹤0.01)。这与总结果保持一致。++[结论]短期接触苯对T淋巴细胞亚群的主要影响是引起CD8+T细胞增加,使机体细胞的免疫紊乱。[Objective] To study the effect of short-term benzene exposure on immune system in shoe factory, workers. [Methods] T lymphocyte subsets were examined by the test of APAAP in 50 shoe factory workers. [Results] Compared short-term benzene exposure with healthy persons, there was no obvious change in CD4^＋ （P 〉 0.05）, but both CD3^＋ and CD8^＋ were significantly risen up （P 〈 0.01）. The CD4^＋/CD8^＋ was obviously reduced （P 〈 0.01 ）. Compared with each other in terms of working age, working place and gender, there was no obvious change in CD3^＋, CD4^＋, CD8^＋ and CD4^＋/CD8^＋ （P〉 0.05） after short-term benzene exposure. Compared with the control group, only CD4^＋ did not change significantly （P 〉 0,05）, while both CD3^＋ and CD8^＋ were all significantly risen up （P 〈 0.01）. The CD4^＋/CD8^＋ was all obviously reduced （P 〈 0.01 ）. This was consistent with the resuh. [Conclusion] The primary change of T lymphocyte subsets in workers with short-term benzene exposure is the increase of CD8^＋, which can cause disorder in immunity.

关 键 词：苯 T淋巴细胞亚群 免疫系统 

分 类 号：R135.13[医药卫生—劳动卫生]