冬凌草甲素亚微乳的制备及其特性表征  

Preparation and characterization of oridonin submicron emulsions

作　　者：于力 仝新勇 谭燕[2] 

机构地区：[1]上海恒瑞医药有限公司,上海200245 [2]上海食品药品监督管理局科技情报研究所,上海200233

出　　处：《中国中药杂志》2009年第20期2590-2593,共4页China Journal of Chinese Materia Medica

摘　　要：目的:制备冬凌草甲素亚微乳,并对其理化性质进行表征。方法:采用高压均质法制备冬凌草甲素亚微乳,并对其粒径、Zeta电位、黏度等性质进行表征。结果:冬凌草甲素亚微乳为白色不透明乳状液体,载药量1g·L-1,平均粒径(138.87±0.60)nm,Zeta电位(47.27±2.31)mV,pH(6.02±0.03),黏度(1.78±0.015)MPa.s。结论:本实验所制得的冬凌草甲素亚微乳理化性质较稳定,工艺简单,可为冬凌草甲素亚微乳制剂的制备提供研究依据。Objective：To prepare the oridonin submicron emulsion and characterize their properties. Method：High pressure homogenization method was employed to prepare the oridonin submicron emulsion and such properties as size,Zeta potential and viscosity were characterized. Result：The results showed that the submicron emulsions was formed with the drug loading 1 g·L^-1,particle size of （138.87±0.60） nm,zeta potential of （47.27±2.31） mV,pH value of （6.02±0.03） and viscosity of （1.78±0.015） MPa·s,respectively. Conclusion：The method is feasible and the submicron emulsions has stable properties. Experiments offer a new formulation of oridonin for clinical application.

关 键 词：冬凌草甲素 亚微乳剂 理化性质 

分 类 号：R283[医药卫生—中药学]