^99Tc^m-tetrofosmin：一种评价体内P-糖蛋白功能变化的显像剂  

^99Tc^m-tetrofosmin： a functional imaging agent of evaluation P-glycoprotein modulation in vivo

作　　者：袁超[1] 李卫鹏[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院核医学科,233004

出　　处：《国际放射医学核医学杂志》2009年第3期144-148,共5页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：^99Tc^m-tetrofosmin是一种制备简便、使用广泛的显像剂，在体内和体外它均为多药耐药蛋白和P-糖蛋白转运的底物。它的特点与^99Tc^m-甲氧基异丁基异腈（^99Tc^m-MIBI）相似但不完全一样。现有的文献提示，有关多药耐药性功能显像和体内多药耐药性功能调节的临床研究可以通过^99Tc^m-tetrofosmin和叩^99Tc^m-MIBI显像来进行，但是两者似乎不能互换。^99Tc^m-tetrofosmin is a widely available and conveniently prepared tracer that has been shown to be a transport substrate for P-glycoprntein and multidrug resistance protein in vitro and in vivo. Its properties are similar but not identical to those of ^99Tc^m-sestamibi. The available data suggest that clinical studies involving imaging of muhidrug resisttanee function and in vivo modulation of muhidrug resisttance function could be performed with ^99Tc^m-tetrofosmin or^99Tc^m-sestamibi, but the two should probably not be used interchangeably.

关 键 词：TETROFOSMIN 抗药性 多药 肿瘤 体层摄影术 发射型计算机 单光子 P-糖蛋白 

分 类 号：R817[医药卫生—影像医学与核医学]