异丙酚对大鼠两侧脑半球各皮质脑电互近似熵的影响  

Effect of propofol on interhemispheric EEG cross-approximate entropy in rats

作　　者：杨静[1] 王威[1] 徐龙河[1] 贾宝森[1] 张宏[1] 

机构地区：[1]解放军总医院麻醉手术中心,北京市100853

出　　处：《中华麻醉学杂志》2009年第9期805-807,共3页Chinese Journal of Anesthesiology

基　　金：国家自然科学基金资助项目（30340075）

摘　　要：目的探讨异丙酚对大鼠两侧脑半球顶叶、额叶和枕叶皮质脑电互近似熵（C—ApEn）的影响。方法雄性SD大鼠36只，体重300～350g，随机分为3组（n=12），分别于左右顶叶（I组）、额叶（Ⅱ组）和枕叶（Ⅲ组）埋置硬膜外电极，连续监测自发脑电。于大鼠清醒状态下连续记录20min脑电图，取最后2min的脑电图进行后期分析并记为基础值；然后静脉输注异丙酚，初始输注速率为400μg·kg^-1·min^-1，每次递增100μg·kg^-1·min^-1，直至900μg·kg^-1·min^-1，每个速率持续输注10min，取最后2min的脑电图进行后期分析，计算不同异丙酚输注速率时两侧脑半球的C—ApEn。于埋置电极前1周时测定不同异丙酚输注速率时大鼠翻正反射和夹尾反射消失情况。结果所有大鼠异丙酚500～600μg·kg^-1·min^-1时翻正反射消失，800～900μg·kg^-1·min^-1时夹尾反射消失。各组给予异丙酚后的C—ApEn均低于清醒状态时，且随异丙酚剂量的增加C—ApEn逐渐降低（P〈0．05）。结论异丙酚可剂量依赖性地降低两侧脑半球顶叶、额叶和枕叶皮质的信息交流和联系。C—ApEn是与异丙酚麻醉效应相关的敏感的非线性脑电参数。Objective To investigate the effect of propofol on interhemispheric EEG cross-approximate entropy （C-ApEn） in rats. Methods Thirty-six male SD rats weighing 300-350 g were randomly divided into 3 groups （n = 12 each）. Pairs of epidural electrodes were implanted in the corresponding areas in the parietal, frontal and occipital cortices respectively. The inffusion rate of propofol was started at 400 μg·kg^-1·min^-1 and increased in 100μg·kg^-1·min^-1 increments every 10 rain until 900 μg·kg^-1·min^-1 . The rats were breathing spontaneously. Interhemispheric EEG C-ApEn of different cortices at different doses were calculated and compared. Loss of rigting reflex and tail-clamping reflex as a function of anesthetic concentration of propofol was tested a week before the epidural electrodes were placed. Results Interhemispheric EEG C-ApEn of the parietal, frontal and occipital cortices decreased dose-dependently as propofol concentration increased. Interhemispheric EEG ApEn of all cortices fell below the awake baseline at 500 and 900μg·kg^-1·min^-1 which also suppressed the righting and tail clamping reflex. Conclusion Propofol decreases the information exchange and connection of the parietal, frontal and occipital cortices in the bilateral hemisphere dose-dependently. C-ApEn is a sensitive non-linear EEG parameter correlated with different anesthetic effects of propofol.

关 键 词：二异丙酚 脑电描记术 熵 

分 类 号：R614[医药卫生—麻醉学]