经主动脉瓣插管左心室辅助的研究  

The study of the feasibility of the tansaortic cannulation in left ventricular assist by animal experiments

作　　者：周健[1] 韩晨俊[1] 吴晓云[1] 李洲斌[1] 徐洪[1] 臧旺福[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院心脏外科,200025

出　　处：《中华实验外科杂志》2009年第11期1410-1412,共3页Chinese Journal of Experimental Surgery

基　　金：上海市科学技术委员会重点科技攻关项目（09441901300）

摘　　要：目的探讨经主动脉瓣插管的左心室辅助方式应用于急性心力衰竭动物模型的可行性。方法在6头猪的急性心力衰竭模型中，尝试经主动脉瓣插管的左心室辅助。并进行血流动力学及心脏超声指标的观察。结果6头猪中有5头完成了实验。它们在血流动力学方面都显示急性心力衰竭状态的建立（P〈0．05）。心超指标未提示经主动脉瓣插管对主动脉瓣、二尖瓣及左心室功能的显著影响（P〉0．05）。在循环辅助下的血流动力学指标及部分生化指标也都较心衰状态有显著改善（P〈0．05）。心脏超声所示的左心室射血分数（LVEF）也有显著改善（P〈0．05）。结论在急性心力衰竭模型建立后，经主动脉瓣的插管对瓣膜及左心室的功能未造成不良影响。这种循环辅助方式可以在短时间内改善急性心力衰竭的状态。Objective To approach the feasibility of using the left ventricular assist by the transaortic cannulation in the acute heart failure animal model. Methods To attempt the left ventricular assist by the transaortic cannulation in 6 acute heart failure pigs. And to observe the hemodynamic and the ultrasonic cardiogram results. Results 5 of 6 pigs finished the total procedure. All of them presented the acute heart failure status by the hemodynamic results （P 〈 0.05）. The Ultrasonic cardiogram didn＇ t show the notable effect of the transaortic cannulation on the aortic valves,the mitral valves and the left ventricular function （ P 〉 0. 05 ）. Comparing with the heart failure status, the circularory assist improved the hemodynamic and the biochemical results （ P 〈 0. 05 ）. The improvement of Left Ventricular Ejection Fraction （LVEF） had also been shown by the ultrasonic cardiogram （P 〈 0.05）. Conclusion It＇ s proved by the experiments that the transaortic cannulation didn＇ t result in harmful effects in valves and in left ventricular function after the establishment of the acute heart failure model. This type of circulatory assist can ameliorate the acute heart failure status in short time.

关 键 词：循环辅助 经主动脉瓣插管 心力衰竭 模型 动物 

分 类 号：R654.2[医药卫生—外科学] R472.9[医药卫生—临床医学]